Hepatoprotective Activity of Flavonoids Purified and Ethanolic Extract from Iraqi Propolis Against Carbon tetrachloride-Induced Liver Damage In Male Mice
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 3
Abstract
The present study aims to investigatethe antioxidant activity of flavonoids purified and methanolic extract from propolis on male mice compared to that caused by carbon tetrachloride as a hepatotoxic model by measuring the determination of catalase, glutathione peroxidase and superoxide dismutase change in liver damage. The results showed that the enzymes antioxidants (Glutothinone peroxidase (GPx) and Superoxide dismutase (SOD) had increased significantly (P <0.0l5) after it has been feeding male mice carbon tetrachloride, and that each of the flavonoids purified at a concentration (500 and 1000 mg / kg) and ethanolic extract at a concentration (500 mg / kg) has led to decreased Glutothinone peroxidase enzyme (GPx) activity significantly (P <0.05) compared to the control treatment after feeding them for 14 days. The ethanolic extract for propolis concentration of 1000 mg / kg and vitamin C concentration of 180 mg / kg has led to increased significantly (P <0.05) when compared with the treatment of control but a level significantly lower (P <0.05) compared with the treatment tetrachloride carbon.Either Superoxide dismutase (SOD) has led flavonoids pure and ethanolic extract for propolis (500 and 1000 mg / kg) to increase significantly the level (P <0.05) compared to treatment tetrachloride carbon, and vitamin C which led to a decline in the level of the enzyme significantly (P < 0.05) when feeding them for 14 days. Either enzyme catalase (CAT) has led flavonoids pure and ethanol extract of propolis (500 and 1000 mg / kg) to decrease significantly (P <0.05) compared to treatment tetrachloride carbon and control group as well as when feeding with vitamin C and ethanol extract alone at a concentration (1000 mg / kg) led to a significant decrease of the level (P <0.05). The study concluded that flavonoids pure and ethanolic extract of Iraqi propolis has led to a reduction of the inhibitory effect as well as for damage to the work of the liver and there by protect members from free radicals and inhibit the liberation of these ROS.
Authors and Affiliations
1Essam F. Al-Jumaily, 1Raghad S. Al-Obaidiand , Jasim M. Abdulla
Keywords
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