In-vivo antipyretic activity of methanolic extracts of root and leaves of Morinda angustifolia Roxb.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 6
Abstract
ABSTRACT: Bangladesh is a country of vast natural resources and plants of utmost values. Over the years, natural products based medical practitioners have been using numerous plants as the panacea of wide range of ailments. By considering the traditional claims, the present study was conducted to evaluate the antipyretic activity of methanolic extracts of root and leaves of Morinda angustifolia Roxb. on Swiss albino mice in which pyrexia was induced injecting brewer’s yeast. The experiment was conducted by dividing the test animals into four groups i.e. group I receiving vehicle double distilled water (DDW) at a dose of 10 mL/kg b.w (body weight) p.o (per orally) as control, group II receiving paracetamol at a dose of 150 mg/kg b.w p.o as standard, group III and group IV receiving methanolic extract of root (MERMA) and leaves (MELMA) of M. angustifolia respectively; both at a dose of 500 mg/kg b.w p.o. After the administration of the samples, rectal temperature of mice was recorded up to 3 hours. Both the extracts along with paracetamol significantly (p<0.05-0.01) reduced temperature when compared to control.
Authors and Affiliations
Baharul Islam*, Syed Mohammed Tareq, Shatabdi Bhattacharjee, Sarrin Shahadat and M. Mohi Uddin Chowdhury
Keywords
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