POSTOPERATIVE ANALGESIA WITH TRANSDERMAL DICLOFENAC VERSUS INTRAMUSCULAR DICLOFENAC – A COMPARATIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 19
Abstract
[b] BACKGROUND[/b]: The search for an ideal drug for postoperative analgesia is ongoing. Diclofenac is commonly used drug for this purpose in different routes. AIMS: To compare the efficacy of transdermal diclofenac with intramuscular diclofenac for postoperative analgesia. [b]SETTINGS AND DESIGN[/b]: This prospective comparative study was conducted in the department of anaesthesiology in a medical college & general hospital. [b]METHODS AND MATERIALS[/b]: The study subjects were 200 patients of both sexes between 18-50 years of age who were scheduled for elective laparoscopic, gynaecological & orthopaedic surgeries on limb. They divided into two groups. Group I received intramuscular injection of diclofenac sodium (75mg) & Group II received transdermal diclofenac diethylamine patch (200mg per 75 sq.cm) postoperatively. The outcome measures were pain intesity, changes in vital parameters, requirment for rescue analgesia & adverse effects. [b]STATISTICAL ANALYSIS[/b]: Parametric data were analysed by using student t-test (unpaired). Non parametric data were analysed by using test of association (chi-square test). [b]RESULTS[/b]: The mean pain score was significantly high in intramuscular diclofenac group (Group I) in laparoscopic & gynaecological surgeries (P = 0.002). Though the mean pain score was different among two groups in orthopaedic surgeries it was not statistically significant (P = 0.377). There were no significant differences in vital parameters & adverse reactions in between two groups. The requirment of rescue anlgesia was significantly more in intramuscular diclofenac group (Group I). [b]CONCLUSIONS[/b]: Transdermal diclofenac is more effective in reducing the intensity of postoperative pain following laparoscopic & gynaecological surgeries but the effect is similar to intramuscular diclofenac in orthopedic limb surgeries
Authors and Affiliations
Soumya Samal, Saubhagya Jena, Basanta Behera
Keywords
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- EP ID EP95573
- DOI 10.14260/jemds/706
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