Predictor factors for relapse after remission of seizure in adults with remote symptomatic epilepsy
Journal Title: International Journal of Medical Science and Public Health - Year 2016, Vol 5, Issue 1
Abstract
Background: Several studies have examined remission in individuals with epilepsy and relied on factors that may affect seizure outcome. However, the information on those patients with remote symptomatic epilepsy who are prone to present remission is quite less. Objective: To evaluate the remission rate and relapse in adult population with remote symptomatic epilepsy. Materials and Methods: Between 2012 and 2013, we performed a retrospective study of epilepsy patients seen in 2007 at the King Abdulaziz Hospital, Jeddah, Saudi Arabia, and followed up subsequently. To be eligible for our study, potential subjects had to meet all the following criteria of symptomatic epilepsy: adult patients 12 years and above with seizures that were the result of one or more identifiable neurological insults of the brain, people with seizure-free period of 2 years and more and followed up by stopping antiepileptic drugs (AEDs), and people with follow-up of at least 2 years after the discontinuation of AED at the first visit in 2001 in which they met the inclusion criteria. Result: The study included 145 patients with remote symptomatic epilepsy. Among most of the patients (80.6%), the type of the seizures was generalized symptomatic epilepsy, while both the focal and generalized types were reported among 16.6% of them. Patients with number of seizures ranged between three and five were significantly less likely to present remission when compared with those with one or two seizures [crude odds ratio (OR) = 0.39; 95% confidence interval (CI) = 0.18–0.83]. Patients who reported history of status epilepticus were significantly less likely to show remission when compared with those with no history of status epilepticus (crude OR = 0.33; 95%CI = 0.13–0.83). Patients who showed abnormal magnetic resonance imaging (MRI) were 57% less likely to exhibit remission when compared with those who showed normal MRI (crude OR = 0.43; 95%CI = 0.23–0.99). Conclusion: Among the acquired causes of symptomatic etiology, the traumatic brain injury is found to be associated with a high rate of remission and good seizure outcome when compared with mesial temporal sclerosis, central nervous system infection, and vascular causes, while the malignant tumor was associated with a high rate of relapse and drug refractory epilepsy.
Authors and Affiliations
Aysha Abdulmalek Alshareef, Madihah Shetewe Alhubayshi
Keywords
Related Articles
- EP ID EP133231
- DOI 10.5455/ijmsph.2016.1808201561
- Views 90
- Downloads 0
Knowledge of premarital screening among male university students in Riyadh, Saudi Arabia
Background: In the Kingdom of Saudi Arabia, where the consanguineous marriage rate is high, premarital counseling is the service offered to young couples on their way to marriage to guide, educate, and prepare the...
Toxic metals levels in cord and maternal blood and possible association with low birth weight of babies
Background: The birth weight of neonates is a reflection of the maternal health, nutritional status, and environmental exposure to toxic metals. Very few studies have evaluated prenatal exposure to toxic metals and its p...
Awareness, perceptions, and use of contraception among married women residing in a village in rural South India
Background: Human fertility is determined by several factors like age at marriage, customs, education, etc. India was the first country in the world to formulate the national family planning program in the year 1952. In...
Physicians knowledge about hand hygiene at King Fahad Hospital of University, Dammam, KSA
Background: Healthcare-associated infections are a serious problem resulting in an extra burden on the patients and the hospitals. Most of these infections occur because of the transmission of microorganisms throu...
A behavioral and serological survey of HIV infection among truck drivers and clients of female sex workers in Benin
Background: Between 2006 and 2012, the HIV rate in Benin remained stable at 1.2%, with some variation occurring between different segments of the population. It is known that truck drivers and clients of female sex worke...