PREDICTORS OF TREATMENT OUTCOME IN PATIENTS WITH INTERSTITIAL LUNG DISEASES IN A TERTIARY CARE CENTRE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 61
Abstract
Interstitial lung diseases represent a large group of more than 200 different entities. Interpretation of clinically relevant disease features and surrogate markers of disease activity can help predict the short- and long-term outcome of patients with interstitial lung diseases. PRIMARY OBJECTIVE To identify the clinico-radiological characteristics influencing the successful outcome of treatment of interstitial lung diseases in a tertiary care centre. SECONDARY OBJECTIVE To find out the pattern of interstitial lung disease in our setting. METHODOLOGY This is a prospective observational study done in the Department of Respiratory Medicine, Medical College, Thiruvananthapuram, from July 2005 to May 2007. The study population included patients with ILD attending the Department of Respiratory Medicine. Sample size was calculated as 71. Outcome variables were defined according to ATS Guidelines 2000. Patients were diagnosed and classified as per international guidelines and treatment started accordingly. Patients were followed up every 3 months or as required by clinical assessment for a minimum of 3 months and a maximum of 18 months. RESULTS A total of 120 patients (58 males and 62 females) were included in the study. 15 patients (12.5%) were lost to followup. Out of 120 patients in the study, 55% had a favourable/stable outcome while 45% had a poor outcome, which included unfavourable response, death, and lost to followup. Factor analysis of our data showed that persons who are not current smokers and nonsmokers have better outcome. Other predictors of successful outcome in order of significance included absence of honeycombing on HRCT, no history of alcoholism, female gender, absence of clubbing, age <50 years, no past anti-TB treatment and a reticulonodular pattern on chest x ray.
Authors and Affiliations
Ronaldwin , Kamala
Keywords
Related Articles
- EP ID EP154497
- DOI 10.14260/jemds/2016/984
- Views 95
- Downloads 0
THE EFFECT OF PHYSICAL ACTIVITY AND ATORVASTATIN ACTION ON LIPID PROFILE OF SEDENTARY AND NON SEDENTARY ALCOHOLIC MYOCARDIAL INFARCTION PATIENTS
[b]BACKGROUND[/b]: World Health Organization estimated 2 million deaths each year because of cardio vascular disease. The sedentary life style and increased lipid levels, obesity, alcohol, smoking and moderniz...
STUDY OF THE EFFECTS OF SILVER NITRATE IN TREATMENT OF ALLERGIC RHINITIS
BACKGROUND Rhinitis is defined as the presence of at least one of the following: congestion, rhinorrhoea, sneezing, nasal itching and nasal obstruction. Other reported symptoms include throat clearing, headaches, facial...
A STUDY OF COMPARISON ASTIGMATISM FOLLOWING MANUAL SMALL INCISION CATARACT SURGERY: SUPERIOR VERSUS TEMPORAL APPROACH
[b]INTRODUCTION: [/b]Cataract surgery has become one of the most common and successful procedures in ophthalmology. In addition to improving visual acuity (VA), one of the goals of modern cataract surgery is to reduc...
AWARENESS OF CHILDHOOD BLINDNESS IN CAREGIVERS OF CHILDREN ATTENDING OPHTHALMOLOGY OPD IN A TERTIARY CARE HOSPITAL IN GOA
BACKGROUND Childhood blindness is a significant problem worldwide. It is associated with child mortality and hence child survival is strongly linked to control of childhood blindness. Visual impairment in early childhood...
TIME OF APPEARANCE OF GOBLET CELLS IN HUMAN SMALL INTESTINE
BACKGROUND Goblet cells form an important component of the lining epithelium of the small intestine. The time of appearance of goblet cells in the human foetus, however, is not widely reported. Few authors have reported...