SERUM URIC ACID LEVEL IN ACUTE ISCHAEMIC STROKE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 36
Abstract
[b] INTRODUCTION[/b]: Stroke entails a high socioeconomic burden due to increased mortality and morbidity. Early identification of individual at risk could be of helpful in designing primary prevention strategies1. The role of serum uric acid (SUA) level as an independent risk factor for stroke has been questioned for many years2. Evidence from epidemiological studies suggest that elevated SUA levels may predict an increased risk for stroke and cardiovascular events2,3. [b]AIMS AND[/b] [b]OBJECTIVES[/b]: 1. study the clinical profile of stroke patient with normal and elevated uric acid. 2. To study the incidence of stroke with normal and elevated uric acid and its correlation with other risk factors (i.e. hypertension, diabetes, alcohol, hyperlipidemia). [b]MATERIAL AND METHODS[/b]: The present study was carried out on 100 patients of acute ischaemic stroke. In each case, the diagnosis of recent ischaemic stroke was confirmed by CT scan of brain. Patients having disease known to increase serum uric acid or taking drugs which can cause hyperuricemia were excluded from study. Detailed clinical and physical examination with relevant investigation was done in all cases and statistical analysis with Chi square and student ‘t’ test were applied wherever appropriate and p value < 0.05 was considered significant.[b] RESULTS[/b]: In present study total 100 cases out of them 54% Patients ware male and 46% patients ware female, majority of patients (62%) were in the age group of 50 to 80 years. Mean age (±SD) of stroke patients was 58.73±13.97 years, Mean serum uric acid (±SD) of hyperuricemic patients 9.52± 2.56 mg/dl, in patient below 60 years 6.01±2.93 mg/dl, in patient above 60 years 6.59±2.40 mg/dl, amongst hypertensive 6.30±2.64mg/dl, amongst diabetic 6.90±3.02mg/dl, Mean SSS Score in patient with elevated serum uric acid was 38.31±11.31 vs. 31.35±12.64 in patient with normal serum uric acid p value equals 0.0116. [b]CONCLUSION[/b]: The prevalence of hyperuricemia in acute ischaemic stroke patients in present study was 29%. Alcoholism amongst male showed statistically significant positive correlation with hyperuricemia in patient with acute ischaemic stroke. Patient with hyperuricemia were having poor neurological status as compared to patients without hyperuricemia when assessed at the time of admission showing statistically significant relation. Outcome was also poor with rising level of serum uric acid but no statistically significant relationship was found in between outcome of patient and hyperuricemia in patient with acute ischaemic stroke.
Authors and Affiliations
Arvind Mangal, Rishi Guria, Manish Singh
Keywords
Related Articles
- EP ID EP159021
- DOI 10.14260/jemds/1231
- Views 142
- Downloads 0
STUDY ON VITAMIN D3 AND LIPID PROFILE LEVELS IN OBESE POPULATION OF NORTH INDIA
There has been a worldwide increase in the prevalence of obesity and a parallel resurgence of vitamin D deficiency. Vitamin D deficiency and low calcium intakes are important risk factors for osteoporosis. The...
HUMAN AMNIOTIC MEMBRANE GRAFTING: A BOON IN OCULAR CHEMICAL INJURIES
Amniotic membrane is the innermost layer of the fetal membranes. It has a stromal matrix, a collagen layer, and an overlying basement membrane with a single layer of epithelium. (1) Amniotic membrane has unique p...
THE CLINICAL STUDY TO ASSESS THE CORNEAL THICKNESS BY USING PACHYMETRY IN VARIOUS TYPES OF REFRACTIVE ERRORS IN AGE GROUP (10 - 40 YRS.)
BACKGROUND The purpose of the study is to measure the corneal thickness in various refractive errors in the age groups 10 - 40 yrs. by using ultrasonic pachymetry and to analyse corneal thickness measured in various refr...
TO COMPARE THE HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION USING THE STANDARD MACINTOSH LARYNGOSCOPE VERSUS VIDEOLARYNGOSCOPE AMONG HEALTHY ADULT INDIVIDUALS RECEIVING GENERAL ANAESTHESIA FOR ELECTIVE SURGERY
BACKGROUND Laryngoscopy and endotracheal intubation are associated with various undesirable effects. The more common response to airway manipulation is hypertension (HTN) and tachycardia mediated by the cardioaccelerator...
A COMPARATIVE STUDY OF MEDIAN AND PARAMEDIAN TECHNIQUES TO IDENTIFY THE LOWER THORACIC EPIDURAL SPACE AND CATHETER INSERTION FOR UPPER ABDOMINAL SURGERIES
BACKGROUND Epidural is a central neuraxial blockade with various applications. The epidural space was first described by Corning in 1901. And Fidel Pages first used epidural analgesia in humans in 1921. Fidel Pages descr...