Spectrophotometric Determination of Cardiovascular Drugs
Journal Title: International Journal of Modern Engineering Research (IJMER) - Year 2013, Vol 3, Issue 5
Abstract
Simple, sensitive, accurate and precise spectrophotometric methods for quantitative determination of cardiovascular drugs viz., Dobutamine Hydrochloride (DOB), Ramipril (RAM), Telmisartan (TEL), Verapamil Hydrochloride (VER) were developed. The method of each drug depends upon oxidation of drugs by Ce (IV) (Excess) and estimating the amount of un reacted Ce (IV) by amaranth dye at 523nm. The calibration curves obeyed Beer’s law over the concentration range of 1.6-12µg ml-1(DOB), 8-56 µg ml-1(RAM), 2-14 µg ml-1(TEL) & 2-12 µg ml-1(VER). The method has been validated in terms of guidelines of ICH and has been applied to analysis of pharmaceuticals.
Authors and Affiliations
K. Sayanna, G. Venkateshwarlu
Keywords
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