UTILITY OF ORAL AND VAGINAL MISOPROSTOL IN THE INDUCTION OF LABOUR: A COMPARATIVE STUDY
Journal Title: Int J of Pharm Res & Analy - Year 2014, Vol 4, Issue 1
Abstract
This study was conducted to compare the efficiency and safety of oral (50 μg) and vaginal (25 μg) misoprostol for labour induction. In this study one Hundred patients with indications for labour induction randomly received 50 μg oral misoprostol every 4 h or 25 μg vaginal misoprostol every 4 h, using maximum four doses. Mean induction time, mode of delivery, rates of tachysystole, oxytocin use, number of doses used, failed induction rate and Intrapartum complication with fetal outcomes were compared for the two groups. Mean dose of misoprostol used for oral and vaginal misoprostol study populations were 2.34 ± 1.05 and 1.96 ± 0.91, respectively. There were two failed inductions in the oral (4%) and one failed induction (2%) in the vaginal group after a total of six doses of misoprostol. Our findings indicated that, 50 μg oral misoprostol has the potential to induce labor as safely and effectively as its 25 μg vaginal analogue. Oral ingestion of misoprostol being easier for the patient and the doctor, orally administered is more preferable than the vaginal route.
Authors and Affiliations
Kamath Rajalaxmi K , Srikar SV
Keywords
Related Articles
- EP ID EP137068
- DOI -
- Views 135
- Downloads 0
RAPID SEPARATION AND ESTIMATION OF LAMIVUDINE AND ZIDOVUDINE IN MARKETED FORMULATIONS USING RP-HPLC METHOD AND ITS VALIDATION
The goal of the present investigation was carried out to develop a validated analytical RP-HPLC method for simultaneous separation and estimation of Lamivudine and Zidovudine for pharmaceutical formulations. The chromat...
DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR DETERMINATION OF ROXITHROMYCIN FROM HUMAN PLASMA
A stable, simple, rapid, precise, accurate HPLC method for analysis of Roxithromycin was developed and validated as per ICH guidelines without need of any internal standard. Separation was carried out using X’terra...
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR ESTIMATION OF TRIFLUOPERAZINE IN BULK AND TABLET PHARMACEUTICAL FORMULATION
ABSTRACT The aim of present research work was to develop and validate UV spectroscopic method for estimation of Trifluoperazine in bulk and tablet pharmaceutical formulation. The method employed simple spectrosco...
DEVELOPMENT AND VALIDATION OF NEW SPECTROPHOTOMETRIC METHODS FOR THE QUANTITATIVE ESTIMATION OF SILODOSIN IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
Three simple, sensitive, accurate and rapid spectrophotometric methods A, B and C have been developed for the quantitative estimation of Silodosin in bulk drug and also pharmaceutical formulations. Method A is a UV...
DEVELOPMENT AND VALIDATION OF NEW RP-HPLC METHOD FOR PACLITAXEL IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
A simple, precise, rapid and accurate reverse phase HPLC method has been developed for the determination of Paclitaxel in bulk and its pharmaceutical dosage form. An enable C18G, 250mm, X4.6mm i.d, 5μm particle siz...