NEPHROPROTECTIVE EFFECT OF LAVANDULA OFFICINALIS L. ETHANOLIC EXTRACT IN ALLOXAN INDUCED DIABETIC RATS
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 9
Abstract
Diabetic nephropathy is chronic complication of diabetes that induced by hyperglycemia with increased generation of ROS, so the present study was conducted to determine the probable nephroprotective activity of Lavandula officinalis L. ethanolic extract in the alloxan-induced diabetic rats. Male rats were divided into four groups as following: control group (HC) received saline (0.9% i.p.); diabetic group (DC) received single i.p. administration of alloxan (120mg/kg b.w); First dose treatment group (FT) received LOE (100mg/kg b.w) i.p. for 21 consecutive days; second dose treatment group (ST) received LOE (200mg/kg b.w) i.p. for 21 days, both treatment groups received a single dose of alloxan (120mg/kg) for inducing diabetes type I. kidney tissue dissected to measure activity of some antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (MDA) by spectrophotometer. Blood samples collected to measure urea and creatinine in the serum. This study revealed that intraperitoneal administration of LOE for 21 days, afforded significant nephroprotection against alloxan-induced elevation in serum marker Urea (38%) and Creatinine (39.45%) P<0.05, kidney antioxidant enzymes activities SOD (72.31%) P<0.01, CAT (42.53%) and kidney lipid peroxidation (45.64%) P<0.05 compared to DC. The present study indicated the nephroprotective effect of LOE in diabetic rats. These effects are in partly due to its potent antioxidant properties.
Authors and Affiliations
Mehrdad Azarmi Aghajan
Keywords
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