Neuro-fuzzy Models as an IVIVR Tool and Their Applicability in Generic Drug Development

Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 2

Abstract

The online version of this article (doi:10.1208/s12248-014-9569-8) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Jerneja Opara, Igor Legen

Keywords

Related Articles

A Novel MDR1 GT1292-3TG (Cys431Leu) Genetic Variation and Its Effect on P-glycoprotein Biologic Functions

P-glycoprotein (P-gp) is a membrane-bound transporter protein that is encoded by the human multidrug resistance gene MDR1 (ABCB1). P-gp recognizes a wide range of xenobiotics, is pivotal in mediating cancer drug resistan...

Bioequivalence for Locally Acting Nasal Spray and Nasal Aerosol Products: Standard Development and Generic Approval

Demonstrating bioequivalence (BE) for nasal spray/aerosol products for local action has been very challenging because the relationship between the drug in systemic circulation and the drug reaching the nasal site of acti...

Population Pharmacokinetics and Pharmacodynamics of Ribavirin in Patients with Chronic Hepatitis C Genotype 1 Infection

We report a population pharmacokinetic (PK) and pharmacodynamic (PD) model of orally administered ribavirin in patients with chronic hepatitis C virus (HCV) infection enrolled in a multicenter clinical trial, including t...

A Network Modeling Approach for the Spatial Distribution and Structure of Bone Mineral Content

This study aims to develop a spatial model of bone for quantitative assessments of bone mineral density and microarchitecture. A spatially structured network model for bone microarchitecture was systematically investigat...

Tiered Approaches to Chromatographic Bioanalytical Method Performance Evaluation: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team

The A2 harmonization team, a part of the Global Bioanalysis Consortium (GBC), focused on defining possible tiers of chromatographic-based bioanalytical method performance. The need for developing bioanalytical methods su...

Download PDF file
  • EP ID EP681065
  • DOI  10.1208/s12248-014-9569-8
  • Views 295
  • Downloads 0

How To Cite

Jerneja Opara, Igor Legen (2014). Neuro-fuzzy Models as an IVIVR Tool and Their Applicability in Generic Drug Development. The AAPS Journal, 16(2), -. https://www.europub.co.uk/articles/-A-681065