Neurobehavioral and Micro Structural Evaluation of the Anti-anxiety Potential of Flaxseed oil Following Rotenone-induced Parkinson’ Disease in Mice
Journal Title: International Neuropsychiatric Disease Journal - Year 2017, Vol 9, Issue 4
Abstract
Aim: This study investigated the neurobehavioral and micro structural anti-anxiety potential of flaxseed oil following rotenone-induced Parkinson’ disease [PD] in mice Study Design: Fifty-six adult male and female mice (Mus musculus) weighing between 23.9-26.3 grams were used for this study. The mice were randomly placed into four groups of fourteen mice each: A (Control; mice pellets), B (Rotenone 3 mg/kg, IP), C (Rotenone + Flaxseed oil 0.3 ml orally), and D (0.3 ml Flaxseed + Rotenone). Place and Duration of the Study: Department of Anatomy, Olabisi Onabanjo University. Between May and September, 2016. Methodology: The brains were excised, weighed and appropriate sections taken and processed histology and labelled with H&E, silver and Nissl stains and immuno-cytochemically with GFAP. Results: The results showed significant (P<0.005) increase in anxiety related activities and neuronal structural derangement, and degeneration of astrocytes in the rotenone-induced Parkinson’s mice, which were counter/ameliorated by flaxseed oil treatments. Conclusion: In conclusion, flaxseed oil acts as a neuro-protective agent against the insult of rotenone model of Parkinson’s disease, thus it should be further evaluated as a potential therapeutic candidate in the management/treatment of Parkinson's disease.
Authors and Affiliations
Philemon Dauda Shallie, Bamidele Richard Babatunde, Olugbenga Olawole Olayinka, Damilola Joseph Talabi, Helen Bassey Akpan, Royhaan O. Folarin, Oluwole Ojo Alese, Oluwadamilola Faith Shallie
Keywords
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- EP ID EP308452
- DOI 10.9734/INDJ/2017/34206
- Views 129
- Downloads 0
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