New Biomarkers in the Diagnosis of COVID-19: Amino Acids
Journal Title: International Journal of Current Medical and Biological Sciences - Year 2022, Vol 2, Issue 2
Abstract
Background:Coronavirus disease 2019 (COVID-19) is still spreading rapidly around the world, and early detection before its severe symptoms begin is important, but challenges in early detection remain. There is also very little data on the effects of COVID-19 on amino acid metabolism.The aim of this study is to analyze the free amino acid profile in the blood serum of COVID-19 patients and to determine their biomarker potential for diagnosis.Materials and Methods: In this study, blood samples were taken from 30 COVID-19 patients and 30 healthy individuals, and their amino acid profile was analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Biomarker and pathway analyzes from multivariate statistical analyzes were performed with the MetaboAnalyst program.Results: Among the amino acids we analyzed, 6 of them were amino acids with strong potential to be used in the diagnosis of COVID-19. According to the AUC value (>0.800), these amino acids are alpha-aminoadipic acid, arginine, proline, alanine, sarcosine and citrulline, respectively. In addition, according to the pathway analysis, it was found that arginine and proline metabolisms were significantly impaired in COVID-19 disease (p<0.001 and impact value: 0.356). Conclusions: This study showed that changes in the amino acid profile of COVID-19 patients may be important in diagnosis, treatment, and prognosis. According to our results, alpha-aminoadipic acid may be an excellent candidate for diagnosis.
Authors and Affiliations
ŞÜKRÜ AKMEŞE, İsmail KOYUNCU, Eyyup Sabri Seyhanli
Keywords
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