New Methods of Treatment for Trophic Lesions of the Lower Extremities in Patients with Diabetes Mellitus
Journal Title: Міжнародний ендокринологічний журнал - Year 2016, Vol 5, Issue 77
Abstract
Introduction. Complications in the form of trophic ulcers of the lower extremities are one of the serious consequences of diabetes mellitus (DM), as they often lead to severe health and social problems, up to high amputations. The aim of the study was the development and clinical testing of diagnostic and therapeutic algorithm for the comprehensive treatment of trophic ulcers of the lower extremities in patients with DM. Materials and methods. Here are presented the results of treatment of 63 patients (42 women and 21 men) with neuropathic type of trophic lesions of the lower limbs or postoperative defects at the stage of granulation. Of them, 32 patients (study group) received local intradermal injections of hyaluronic acid preparations and sodium succinate (Lacerta) into the extracellular matrix. Patients of the comparison group were treated with hydrocolloid materials (hydrocoll, granuflex). The level of glycated hemoglobin, the degree of circulatory disorders (using ankle brachial index, before and after the test with a load) and neuropathic disorders (on a scale for the evaluation of neurologic dysfunctions — NDS) were assessed in patients. Results. The results of treatment were assessed by the rate of defect healing during 2 or more months. In the study group, 24 patients showed complete healing of the defect (75 %), while in the control group the healing was observed in 16 patients (51.6 %). During the year, relapses occurred in 22.2 % of cases in the study group, and in 46.9 % — in the control one (p < 0.05). Conclusion. The developed method of treatment using Lacerta allowed to increase the effectiveness of therapy, to speed recovery, to decrease a number of complications in patients with DM and trophic ulcers of the lower extremities.
Authors and Affiliations
S. V. Bolgarska, O. V. Ponomarenko
Keywords
Related Articles
- EP ID EP200111
- DOI 10.22141/2224-0721.5.77.2016.78753
- Views 74
- Downloads 0
Comparative analysis of the activity of cells of innate immunity in patients with benign and malignant thyroid diseases after radioiodine therapy
Background. The effects of radioiodine therapy (RIT) on the cytotoxic activity of NK cells and the metabolic activity of neutrophils (NPs) were studied in patients with toxic goiter (TG) and differentiated thyroid carcin...
Influence of preparation of BNO 1030 on pro-/antioxidant status of the blood in experimental type 1 diabetes mellitus
Background. Among the mechanisms that lead to the development and deterioration of the diabetes mellitus type 1 (DM1) and its complications, an important role belongs to the intensification of oxidative stress. In the de...
The Content of Insulin-Like Growth Factor 1 and Essential Trace Elements in the Blood Plasma of Children with Different Forms of Short Stature
The content of insulin-like growth factor 1 and essential trace elements (zinc, selenium, copper, manganese, chromium) was studied in the blood plasma of children with short stature, depending on the etiology of the dise...
Predicting the Risk of Preeclampsia in Pregnant Women with Type 1 Diabetes Mellitus and Concomitant Diabetic Nephropathy: the Role of Genetic Markers
Introduction. Systematic reviews found that in diabetic nephropathy, there is a 2-fold risk of adverse effects for the fetus, and 5-fold — for the mother. Most complications in patients with diabetic nephropathy are medi...
Orphan Hereditary Syndromes in the Practice of Pediatric Endocrinologist
The lecture presents short phenotypic and genetic characteristics of orphan endocrine syndromes associated with gigantism.