New Resveratrol Analogues for Potential Use in Diabetes and Cancer
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 6, Issue 2
Abstract
Resveratrol is a well notorious compound that may play a role in the prevention of diabetes complications and different cancers. Along, resveratrol, a naturally occurring phytoalexin, is known to exert numerous beneficial effects in the organism. Isolation of resveratrol from plants, however, has been proved being difficult. Importantly, the bioavailability in the body is poor therefore capability is reduced and not enough resveratrol reaches the target organ. In this study we generated different methoxylated resveratrol analogues using Wittig reaction. trans stilbene obtained was 0.08 g and the cis one was 0.01 g. Additionally with the Horner-Witting method a yield of 0.15 g trans stilbene was obtained. By substituting the hydroxyl group with methoxy group at different positions on the aromatic rings, we could increase the efficacy and bioavailability of the trans form of resveratrol. Diabetes is known as a chronic metabolic condition of having higher than normal blood sugar levels [1]. It involves β cells in the pancreas, which secrete a hormone called insulin. There are two types of diabetes: Type 1 and Type 2. Type 1 diabetes occurs when no insulin is being produced by the pancreas and is also known as insulin-dependent diabetes. Type 2 diabetes appears when there is relative insulin deficiency as such it increased glucose production by the liver and decreased utilization of glucose in the peripheral tissues [2]. It is well known that Type 2 diabetes can be genetically inherited and can be influenced by a number of factors such as diet, stress, alcohol consumption and lack of exercise [3]. Since the number of people diagnosed with diabetes has increased enormously, this disease is nowadays considered the 6th cause of worldwide mortality [4]. Because of the heightened aging of population and overweight people, it is estimated that by 2025 roughly 5 million people will have diabetes [4,5]. There are distinct classes of drugs which treat diabetes. Essentially, different types of insulin and as a second line treatment are the Sulphonylureas class. This class of drug cannot be taken by obese people because one of the adverse reactions is weight gain [6]. It appears clear that new treatments are urgently required to properly manage the different forms of diabetes [7-10]. Resveratrol is a stilbenoid and a phytoalexin which belongs to the large group of polyphenols found in different plant species [1]. The name stilbene (Figure 1), 1,2-diphenylethylene was derived from the Greek word stilbos, which means shining [3]. Phytoalexins are a group of phytochemicals of low molecular weight which are produced when plants are attacked by pathogens [2,3]. The richest natural source of resveratrol is Polygonum cuspidatum [3,5]. Also, resveratrol is synthesized in the skin cells of the grapes [11].
Authors and Affiliations
Keti Zeka, Randolph RJ Arroo, Dritan Hasa, Kenneth JM Beresford, Ketan C Ruparelia
Keywords
Related Articles
- EP ID EP592329
- DOI 10.26717/BJSTR.2018.06.001339
- Views 163
- Downloads 0
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