NEW SPECTROPHOTOMETRIC DETERMINATION OF PREGABALIN BULK AND PHARMACEUTICAL DOSAGE FORM
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 6
Abstract
A new, selective and sensitive visible spectrophotometric method have been developed for the estimation of Pregabalin in bulk and pharmaceutical preparations. The method is based on the reaction of pregabalin with 2, 3- dichloro-5, 6-dicyano-1, 4-benzquinone (DDQ) to form red colour charge–transfer complex with a λmax. 465nm extracted in methanol. Beer’s law is obeyed in the concentration range of 50 to 250μg/ml for the method. The method is extended to pharmaceutical formulations and there was no interference form any common pharmaceutical excepients and diluents. The result of analysis has been validated statistically and by recovery studies.
Authors and Affiliations
Dr. A. J. Pratapa Reddy| Department of chemistry, K.V.R.P.G College, Nandigama, India.
Keywords
Related Articles
- EP ID EP1406
- DOI -
- Views 410
- Downloads 33
STUDIES ON PHENOTYPIC TRAITS AND GENETIC VARIABILITY IN ERG 11 GENE AMONG DRUG RESISTANT CANDIDA SPECIES
Candida is an opportunistic pathogen of human beings and other mammals. It is the leading agent of various types of diseases in immunocompromised individuals. The most common infecting species is C. albicans where as oth...
LIPOSOMES IN DRUG DELIVERY SYSTEM: A REVIEW
Amongst various medicament carrier systems, liposomes have generated a great interest because of their versatility. Liposomes not only used in delivery of both hydrophilic and lipophilic medicaments for cancer, diagnosti...
BILATERAL CONGENITAL GLAUCOMA IN NEUROFIBROMATOSIS TYPE 1 AND MANAGEMENT. (A RARE - CASE REPORT)
Neurofibromatosis 1 is a genetic disorder of neural crest-derived cells. Riccardi classified NF into 8 subtypes NF-I to NF-VIII. NF-V is segmental NF (Prevalence 0.0014 and 0.002%) Caused by a Postzygotic somatic mutatio...
ANTIOXIDANT ACTIVITY OF HERBAL PLANTS: A RECENT REVIEW
Antioxidants or inhibitors of oxidation are compounds which retard or prevent the oxidation and in general prolong the life of the oxidizable matter. Majority of the diseases/disorders are mainly linked to oxidative stre...
JAHN-TELLER DISTORTIONS: A NEW STRATEGY IN QUANTUM MECHANICS
The concepts of the Jahn-Teller effect and vibronic coupling are being applied to more and more systems in both chemistry and physics. Aspects of structural chemistry such as the distortion of the nuclear framework to a...