New Therapeutic Possibilities of Type 2 Diabetes Mellitus Management: Experience of Voglibose Application
Journal Title: Міжнародний ендокринологічний журнал - Year 2014, Vol 6, Issue 62
Abstract
Objective of the study — an estimation of efficiency of application and tolerability of new alpha-glucosidase inhibitor voglibose (Voxid) in the treatment of patients with type 2 diabetes mellitus (DM). Material and Methods. We have examined 20 patients with type 2 DM aged from 32 to 65 years, who did not have satisfactory glycemic control during previous treatment. Before the beginning of research and during all supervision they received previous hypoglycemic therapy (metformin and glimepiride). The total duration of patients’ participation in the study was 3 months and included four visits: an initial visit, the first and second months — interim visits; 3 months later — the final visit. HbА1c was measured during the first and last visits. Patients with type 2 DM were additionally administered voglibose (Voxid, produced by LLC «Kusum Pharm», Ukraine) at a dose of 0.2 mg before breakfast, lunch and dinner for three months as a part of combination oral hypoglycemic therapy. Results. After 3 months of voglibose application, fasting glucose content decreased by 1.8 mmol/l and was 7.4 ± 0.3 mmol/l. During the fourth visit, the level of postprandial blood glucose against combined therapy with the addition of Voxid significantly decreased by 2.6 mmol/l, НbA1c — by 1.2 %. There was a trend to a decrease in body mass index in surveyed patients (by 1.1 kg/m2), but it did not reach statistical significance. The positive clinical effect of the drug in ours study was achieved at an average of 0.75 mg Voxid a day. Treatment with Voxid was safe for patients and well tolerated. Conclusions. Application of Voxid (voglibose) in combination therapy of type 2 DM for three months resulted in a statistically significant improvement in the main indicators of metabolism and insulin resistance reduction.
Authors and Affiliations
V. I. Pankiv
Keywords
Related Articles
- EP ID EP229530
- DOI -
- Views 65
- Downloads 0
Male factor of sterility: algorithm of laboratory diagnosis of the causes (part 2)
Previously, the topics of laboratory diagnosis were covered: assessment of the male androgenic status: what to choose — total or free testosterone; or use an estimated indicator — free testosterone index; what is importa...
Hypothalamic Syndrome
No abstract
Blood glucose level and insulin resistance in patients with type 2 diabetic mellitus, diabetic retinopathy and obesity
Background. Diabetic retinopathy is the main cause of visual disorders in the world. The purpose of our work was to study the level of glycaemia and insulin resistance in patients with type 2 diabetes mellitus (DM), diab...
Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease
This article estimates the role of Gln27Glu polymorphism of β2-adrenergic receptors gene in forming violations of carbohydrate and lipid metabolism in obese patients with ischemic heart disease. A comprehensive survey of...
Genetic basis of endocrine pathology
The purpose of the review was analysis of literature data relating to the molecular genetic basis and diagnosis of endocrine pathology. We searched for published and unpublished researches using Pubmed as the search engi...