Newborn Screening for Sickle Cell Disease (SCD) in Awka South East Nigeria
Journal Title: Journal of Blood Disorders & Transfusion - Year 2018, Vol 9, Issue 2
Abstract
Background: Sickle cell Diseases (SCD) is a genetic disorder. It is the most common genetic disorder affectingblack race worldwide. It carries a high mortality and morbidity when not promptly and properly managed. Earlydetection is key to improving the quality of life of people living with sickle cell disease especially in childhood. It hasresulted in reduction in mortality rate of SCD to <1% in developed countries through new-born screening but thisreduction is yet to be achieved in developing countries.Objective: To share the experience of new-born screening of SCD at COOUTH Awka. To determine theprevalence of Sickle cell disease among neonates in Anambra State.Methodology:A retrospective study of screening for SCD in new-borns carried out at Chukwuemeka OdumegwuOjukwu University Teaching Hospital (COOUTH) Awka from 1st September 2013 to 27thOctober 2017. This wasdone using isoelectric focusing machine.Results: A total of 4961 children were screened, 2410 were males, while 2551 were females. 75% (3733) of theneonates had their hemoglobin genotypes as AA, while 0.3% (16) were Hb SS genotype. Prevalence of Hb SSgenotype amongst newborns was 0.32%.Conclusion:This study found the prevalence of sickle cell disease in newborns to be 0.32%. Newborn screeningusing Isoelectric focusing machine is very valuable for early diagnosis and prompt management of SCD. There istherefore need for increased awareness of this in Anambra State
Authors and Affiliations
Ejiofor OS, Efobi C, Emechebe GO, Ifezulike CC, Okeke KN, Mokebe TC, Obijiofor K, Ideh CC, Onuh U
Keywords
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- EP ID EP582627
- DOI 10.4172/2155-9864.1000398
- Views 118
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