Ninety days repeated dose oral toxicity study of Maruthampattai kudineer in Wistar rats
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2019, Vol 5, Issue 6
Abstract
Context: Maruthampattai kudineer (MP) is polyherbal siddha formulation recommended for diabetes mellitus in the classical text Agathiyar 2000. The present study was carried out to evaluate the repeated dose oral toxicity of MP to generate evidence for safety and global acceptance of the drug. Aim: The objective was to evaluate toxicological profile and to find no observed adverse effect level (NOAEL) in rats after oral administration for ninety consecutive days. Materials and Methods: Maruthampattai kudineer was administered to male and female Wistar rats for ninety consecutive days at 900, 1800, 3600mg/kg body weight. All relevant biochemical and hematological changes were observed. At termination, all the rats were sacrificed and necropsy was performed. Histopathological evaluation was also performed. Statistical Analysis Used: Values are expressed as mean ± SD Statistical significance (p) calculated by one way ANOVA followed by dunnett‟s. P< 0.05 considered as significant by comparing treated group with control group using Graph Pad Prism 3.0. Results: The repeated dose study did not show evidence of any treatment related changes in all observations up to the high dose level, when compared with the control. Histopathological examination revealed no abnormalities in high dose group. This study provides scientific validation for the safety of MP.
Authors and Affiliations
B. Vinubharathi1*, V. Mahalakshmi2 , N. J. Muthukumar3
Keywords
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- EP ID EP575346
- DOI 10.22192/ijcrms.2019.05.06.003
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