No association between the brain-derived neurotrophic factor 196G>A or 270C>T polymorphisms and Alzheimer’s or Parkinson’s disease
Journal Title: Folia Neuropathologica - Year 2006, Vol 44, Issue 1
Abstract
The brain-derived neurotrophic factor (BDNF) promotes survival, differentiation and maintenance of neurons in the central nervous system. BDNF 196G>A and 270C>T polymorphisms have previously been associated with Alzheimer’s disease (AD) and with Parkinson’s disease (PD). To study the role of BDNF 196G>A and 270C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196G>A and 270C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction. No associations were found between the genotypes studied and AD or PD in Finnish patients. Moreover, no interaction between either BDNF polymorphism and the ε4 allele of apolipoprotein E was found. In conclusion, it seems that the BDNF gene does not contribute significantly to the risk of AD or PD in Finnish patients.
Authors and Affiliations
Marika Saarela, Terho Lehtimaki, Juha Rinne, Heini Huhtala, Riikka Rontu, Antti Hervonen, Matias Röyttä, Jukka-Pekka Ahonen, Kari Mattila
Keywords
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