No association of glucocorticoid receptor gene polymorphism (rs6190) with unipolar and bipolar disorder
Journal Title: Psychiatria Polska - Year 2013, Vol 47, Issue 4
Abstract
Aim. Functional polymorphism ER22/23EK glucocorticoid receptor leads to reduction of its resistance and to increase in its sensitivity to the glucocorticoid that regulate the functioning of the axis hypothalamus - pituitary - adrenal glands. Disturbances in the regulation of this axis are observed in patients with psychiatric disorders. The aim of this study was to demonstrate the association ER22/23EK polymorphism with bipolar disorder and major depressive disorders. Methods. In the study 144 patients with unipolar disorders and 479 patients with bipolar disorder were included. Patients were diagnosed by two psychiatrists on the basis of medical records and interview based on SCID criteria (Structured Clinical Interview for DSM Disorders). The control group comprised 595 healthy subjects. As the research material peripheral blood was used, from which DNA was obtained. Genotyping was performed using PCR - RFLP method. Results. No association of ER22/23EK polymorphism with unipolar disorder or with bipolar disorder was found. GA genotype was not observed in any of the subjects. Conclusion. ER22/23EK functional polymorphism of the glucocorticoid receptor gene is not associated with unipolar and bipolar disorder.
Authors and Affiliations
Dominika Nemec, Aleksandra Szczepankiewicz, Anna Leszczyńska-Rodziewicz, Joanna Pawlak, Monika Dmitrzak-Węglarz, Maria Skibińska
Keywords
Related Articles
- EP ID EP104174
- DOI -
- Views 126
- Downloads 0
Associations between candidate genes with schizophrenia susceptibility and the treatment efficiency
Aim. The aim of the study was to find genetic markers which can have influence on susceptibility of paranoid schizophrenia and the treatment efficiency measured by the PANSS (Positive and Negative Syndrome Scale). We ana...
Biomarkery nadużywania alkoholu. Część II. Nowe biomarkery oraz ich interpretacja
Coraz więcej nowych biomarkerów nadużywania alkoholu jest opisywanych w literaturze. W pracy omówione zostały biomarkery najczęściej używane (5-hydroksytryptofol, estry etylowe kwasów tłuszczowych, glukuronian etylu, fos...
Assessment of severity of depressive symptoms using the Polish version IA of Beck Depression Inventory in healthy men, inhabitants of Wrocław
Background. Aging is accompanied by progression of depressive symptoms, which significantly impair the prognosis and quality of life of elderly men. Currently, there are no Polish reference values reflecting age-related...
Metabolic syndrome and cognitive dysfunction in the old age
Background. We analyzed metabolic profile of patients with cognitive dysfunctions by means of levels of lipoproteins, glycaemia and hypertension. Research design and methods. In naturalistic, open manner, we studied 100...
Syndrome of inappropriate antidiuretic hormone secretion in the course of treatment with venlafaxine – case report
Treatment with some drugs may induce hyponatraemia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This is a report of a 52-year-old man who developed hyponatraemia after starting venla...