Normative data of the urinary bone resorption biomarkers for osteoporosis DPD, CTx and NTx among females in Manipur and its correlation with bone mineral density measured by DEXA scan
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction Osteoporosis has become a major public health problem affecting more than 100 million people worldwide Standard diagnosis depends on measuring bone mineral density BMD using a dual energy Xray absorptiometry DEXA Bone turnover markers are metabolic products that mediate bone metabolism and can provide information regarding bone formation or resorption before the structural changes of bone occur BMD and bone markers complement each other and provide comprehensive information about a patients bone status and bone activityAim To find the correlation between selected urinary bone turnover markers and bone mineral density measured by DEXA scanMaterials and Methods A cross sectional study was conducted among 2700 pre and postmenopausal women with intact ovaries aged between 21 to 70 years in three districts of Manipur Performance of three urinary markers of bone turnover ie Deoxypyridinoline DPD Ntelopeptide NTx and Ctelopeptide CTx were assessed and correlated with the bone mineral density Tscore measured by DEXA scanResults Significant correlation was found between DEXA Tscore and NTx r0070 pConclusion It can be concluded that there is significant correlation between DEXA Tscore and NTx but not for DPD and CTxClinical Significance In the management of osteoporosis bone markers can be used for determining the response to antiresorptive treatment amongnst which NTx of collagenI may be suggested to assess bone resorption for Manipuri womenKeywords Cross sectional study DEXA Deoxypyridinoline C telopeptide N telopeptide Osteoporosis
Authors and Affiliations
Akoijam Joy Singh, Kanti Rajkumari, Tripti Khanna
Keywords
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- EP ID EP475428
- DOI 10.18231/2394-6377.2018.0116
- Views 75
- Downloads 0
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