NOVEL COMPOUNDS WITH ANTIULCEROGENIC POTENTIALS UNVEILED IN PLANTAIN LEAVES ISOLATES (MUSA PARADISCIACA)
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2017, Vol 5, Issue 2
Abstract
Ethanolic extract of plantain leaves was tested on forty eight ethanolic induced gastric ulcer rats for 28 days. The extract was found to posses potent antiulcerogenic effects. The isolates of such was analysed with Nuclear magnetic resonance (NMR) equipment and found to have antiulcerogenic compounds. The compounds have two carbon atoms without hydrogen bonding at 13C NMR with 29.430 PPM and at 62.097PPM of isolate A and B respectively. The isolates displayed same characteristics in hydrogen and carbon atoms indicating that they may be the same compound. This characterization has shown a structure of a compound that has not been characterized before and the new potent herbal drug for the treatment of gastric ulcer.
Authors and Affiliations
JIMMY| DEPARTMENT OF HUMAN PHYSIOLOGY, FACULTY OF BASIC MEDICAL SCIENCES, UNIVERSITY OF UYO, AKWA IBOM STATE, NIGERIA, E. O. | DEPARTMENT OF HUMAN PHYSIOLOGY, FACULTY OF BASIC MEDICAL SCIENCES, UNIVERSITY OF UYO, AKWA IBOM STATE, NIGERIA
Keywords
Related Articles
- EP ID EP1674
- DOI -
- Views 454
- Downloads 29
Spectrum of histopathological lesion in surgically removed appendix
The background to this debate about legitimising cannabis (also called marijuana)—from the plant Cannabis sativa for analgesic use is that the drug has been used both therapeutically and recreationally for thousands of y...
CURRENT SCENARIO OF PHARMACOVIGILANCE IN INDIA
Even though Pharmacovigilance is still in its infancy in India, it is not new to India and still there exists very limited knowledge about the discipline. While major advancements of the discipline of pharmacovigilance h...
FORMULATION AND DEVELOPMENT OF ENTERIC COATED ORNIDAZOLE TABLET FOR COLON TARGETED DRUG DELIVERY SYSTEM
Lactose-based placebo tablets were prepared and coated using various combinations of Eudragit L100 and Eudragit S100, by spraying from aqueous systems. The Eudragit L100 Eudragit S100 combinations (w/w) studied were 1:0,...
Topical gel: a novel approach for pain relief treatment
The main advantage of topical delivery system is to bypass the first pass metabolism, avoidance of the risk and annoyance of intravenous therapy and of the varied conditions of absorption, like pH changes, gastric emptyi...
Review article on anti-inflammatory activity of various herbal plants and various animal models
Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, injured cells or irritants. It is characterized by redness, inflamed joints, joint hurt, loss of joint...