NOVEL SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF SCHIFF BASES OF KETOPROFEN HAVING HETEROCYCLIC MOIETY
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2012, Vol 1, Issue 2
Abstract
A new series of two Schiff bases of ketoprofen having heterocyclic moiety have been synthesized in present investigation. We have tested the anti-inflammatory activities of the synthesized compounds in vivo by using carrageenan induced edema model, using ketoprofen as standard. The safety of these newly synthesized derivatives is reflected by toxicity studies.
Authors and Affiliations
Harendra K. Sharma*| Department of Chemistry, Bethesda Institute of Technology and Sciences, Gwalior (M.P.) India 474006, Manoj Sharma| Department of Pharmacology, Shri RNS College of Pharmacy, Gormi, Bhind, India, Vinay Thakur| Department of Chemistry, Mithibai College, Mumbai (Maharastra) India-400056, Gajanan Pandey| Department of Applied Chemistry, Madhav Institute of Technology and Science, Gwalior-474005 (M.P.) India
SEROFREQUENCY OF DENGUE VIRUS AMONG FEBRILE PATIENTS ATTENDING PORTSUDAN TEACHING HOSPITAL
Background: With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. This study aimed to determine the...
Floating Tablets for Helicobacter Pylori Induced Peptic Ulcer Therapy: A Research Review on Formulation Studies, In Vitro and In Vivo Evaluation
The purpose of writing this review on floating drug delivery system (FDDS) is to compile the recent research literature with focus on the gastro retentive tablet dosage forms. FDDS are of particular interest to deliver d...
Interaction of tau proteins and orexin receptors in dementia and allied syndromes
The neuronal and neurobiological basis of cognitive dysfunction accompanying neurodegenerative processes forms an important focal point of research interest in neuroscience. The so-called‚ mild cognitive impairment refer...
Effect of Ethanolic Extract of Leaf of Piper Betle Linn as Immunomodulatory Agent: A Unique Role of Phytochemicals.
Background: Biochemical and immunological effect of leaf of Piper betle Linn in rat were studied. Objective: To evaluate the immunomodulatory effect of leaf of Piper betle Linn. Methods: Ethanolic EXTRACT OF LEAF OF Pipe...
ESSENTIAL ASPECTS OF WATER SAFETY: A CASE STUDY ON ROAD SIDE HAWKERS IN DELHI, INDIA
Drinking water quality assessment in Delhi region has always been crucial with reference to public health importance. A study was conducted to evaluate the quality of drinking water sold by roadside hawkers. A total numb...