NUTRIGENOMICS: A NEW PARADIGM FOR REVEALING PERIODONTAL INTERRELATIONSHIPS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 1
Abstract
Improved understanding of the mechanism behind periodontal tissue devastation, the potential protective role of nutrients and the advent of modern genomic measurement tools have led to an increased interest in the association between nutrition and periodontal disease. Nutrigenomics is an emerging field of science and technology revealing inter-relationships between nutrients and human genome using modern tools such as transcriptomics, metabolomics, epigenomics and proteomics. It implies that nutrition and genetics both play a significant role in the maintenance of human health as well as the development of lethal diseases. Nutrition may be important in redressing the balance between microbial challenge and the host response because it has been implicated in a number of inflammatory diseases and conditions, including type II diabetes mellitus, cardiovascular diseases, rheumatoid arthritis and inflammatory bowel disease, all of which have also been associated with periodontal diseases. Based on the pathology of periodontal disease, the assumption is that specific nutrients which can modulate immune and inflammatory responses could in turn modulate periodontal health. Antioxidant vitamins and trace elements which are known to be depleted during periods of inflammation can counteract reactive oxygen species damage to cellular tissues and modulate immune-cell function through the regulation of redox-regulated transcription factors and ultimately affect the production of cytokines and prostaglandins, thus leading to periodontal changes. Thus we now have the opportunity to study nutrient-gene interactions and how diet affects the inflammatory mechanisms underlying severe periodontitis.
Authors and Affiliations
Dr Shilpa Shivanand*| Post Graduate Student, Department Of Periodontology, Rajarajeswari Dental College and Hospital., Dr Savita S| Principal, Professor and Head of the Department, Department of Periodontology, Rajarajeswari Dental College and Hospital., Dr Rithesh K| Reader, Department of Periodontology, Rajarajeswari Dental College and Hospital., Dr Navnita Singh| Post Graduate Student, Department of Periodontology, Rajarajeswari Dental College and Hospital.
Keywords
Related Articles
- EP ID EP3672
- DOI -
- Views 392
- Downloads 22
Impact of High EGCG Consumption on Mouse Liver
Tea is one of the most popular beverages especially among Middle East countries. Epigallocatechin 3-gallate (EGCG), the principal component of green tea is known to have many beneficial effects in therapeutic doses. Howe...
Novel Drug Delivery System (NDDS): Niosomes.
Different carriers like liposomes, niosomes, microspheres, resealed erythrocytes, dendrimers, aquasomes, trasfersomes, ethosomes, phytosomes, nanoparticles etc. are used in novel drug delivery system. Vesicular systems a...
Prescribing Pattern of Antibiotics in Intensive Care Unit of a Tertiary Care Teaching Hospital
Antibiotics are the most commonly administered drugs in ICU. By optimizing the use of antibiotics within ICU, patient outcomes are improved, better initial antibiotics administration is provided, and the chance of furthe...
THE ANTIMICROBIAL EFFECT OF AQUEOUS EXTRACT OF TAMARIND (TAMARINDUS INDICA) LEAVES
This study is comparative-experimental work. It was conducted in National Center for Research (Sudan) during the period from 28th of August to 20th December 2013 to investigate the antimicrobial activity of aqueous extra...
Optimization of dispersive liquid-liquid microextraction followed by flame atomic absorption determination of Cu (II), Ni (II) and Co (II) based on the complexation reaction with phenathrene-9, 10-dine dioxime (PD)
In this study, a dispersive liquid-liquid microextraction (DLLME) method was used for preconcentration of Cu (II), Ni (II) and Co (II) cations from water samples. Oxime (phenathrene-9, 10-dine dioxime (PD)) was used as...