Observation on The Efficacy And Outcome of Artesunate Versus Quinine Therapy in Complicated Malaria
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Background: complicated malaria is the most dangerous and notorious complication of severe falciparum malaria. In the present study 100 cases with clinical features of complicated malaria (WHO criteria) were included and randomly allocated into two equal groups. One group received i.v. quinine and the other group received i.v. artesunate. Objective: To find out the outcome in terms of relative efficacy and overall cure rate for both drugs, employed for therapy. Methodology: The study was carried out in the Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi in which Patients presenting with features of severe malaria and positive blood film for P. falciparum were taken for study,excluding those with no asexual form of P. falciparum or with multispecies forms of malarial parasite in peripheral smear, G6PD deficient cases and cases with hepatitis or renal failure due to other causes. result: Maximum number of patients recovered from coma within 24- 48 hours in artesunate group (43%), while only 26% in quinine group . artesunate showed Faster fever clearance time (median = 49.66 hours) than with quinine (median= 63.78 hours).artesunate group showed significantly less parasite clearance time as compared to quinine group (median = 54.7 hours). Toxicity and side effects of drugs where much less in patients taking artesunate than those taking quinine with no significant difference in mortality.
Authors and Affiliations
Dr. Divya Singh, Dr. Arun Kumar Sharma
Keywords
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- EP ID EP598006
- DOI 10.9790/0853-160508115119.
- Views 91
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