OBSERVATION ON TOXICITY OF INTRAVENOUS AMPHOTERICIN-B IN DIAGNOSED CASES OF KALA-AZAR IN DAILY VERSUS ALTERNATE DAY REGIMEN
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2014, Vol 1, Issue 13
Abstract
Visceral leishmaniasis (Kala-azar) is a disease caused by a protozoan parasite, Leishmaniasis donovani and transmitted by the bite of sand fly vector Phlebotomus argentipes. For patients with Indian visceral leishmaniasis, Amphotericin-B deoxycholate is usually given as 15 alternate-day infusion of 0.75mg/kg over 30 days; daily treatment with 0.75mg/kg body weight is also used. An observation of toxicity of intravenous Amphotericin-B in diagnosed cases of Kala-azar on daily versus alternate day regimen on a dose of 0.75mg/kg body weight was compared. Results revealed that daily regimen of Amphotericin-B in a dose of 0.75 mg/kg body weight can be given safely to patients and this regimen can not only reduce the financial burden on the patients but can also reduce hospital stay.
Authors and Affiliations
Vishal Parmar, Rakesh Kumar, Mehre Darakhshan Mehdi, Pramod Kumar Agrawal, Yadu Nath Giri
Keywords
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- EP ID EP226876
- DOI 10.18410/jebmh/2014/242
- Views 91
- Downloads 0
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