Okara Gum: A natural polysaccharide based carrier for preparation of microbially triggered colon targeted drug delivery system
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2014, Vol 1, Issue 1
Abstract
Colon targeted pulsatile systems are best for drugs which follow chronopharmacological behavior where, night time dosing is required, drugs have high first-pass effect and specific site of absorption in GIT. In this study, colon targeted pulsatile release tablets of atenolol was prepared using press coating technique to treat hypertension in the early hours of the morning. Pulsatile release of atenlol in colon was achieved by press coating of atenolol core tablet using biodegradable polysaccharides. A biodegradable polymer is a polymer in which the degradation results from the action of naturally occurring microorganisms such as bacteria, algae or fungi. The inability of GIT enzymes to digest certain plant polysaccharides (pectin, guar gum, okara gum) is taken as an advantage to develop colon specific drug delivery systems. The aim of this study is to find out the suitability of newer polysaccharide okara gum for colon targeting of atenolol by compression coating atenolol core tablet with okara gum. The minimum coat weight of okara gum require for colon targeting is optimized. OG4 press coated tablet having 250 mg coat weight of okara gum showed 6 hr lag time and near 7 hr T85%, which is applicable pulsatile drug delivery of atenolol for treating early morning hypertension.
Authors and Affiliations
Rajesh A Keraliya, Chirag A Patel, Vipul Keraliya, Madhabhai M Patel
Keywords
Related Articles
- EP ID EP274234
- DOI -
- Views 122
- Downloads 0
Ethnomedicinal uses of Pteredophytes in Marunthuvazhmalai Hills of Kanyakumari Wildlife Sanctuary, Southern Western Ghats
The study focuses on the ethno-medicinal significance of Pteridophytes which are widely used by the local people of Marunthuvazhmalai hills, southern Western Ghats. A total of 25 species of pteridophytes were collected f...
A Case Study on Efficacy of Chaturjatak Taila Pratimarsh Nasya & Shatyadi Churna (Internally) for the Management of Pratishyaya w.s.r. to Allergic Rhinitis
Pratishyaya (Allergic rhinitis) is one of the most common and most prevalent disease, familiar to all with an equal distribution more or less throughout the world, rather without any exception to the developed and under...
A Conceptual Study of Understanding the Effects of Phthalates on Human Health and its Management with special reference To Dooshi Visha (Cumulative Toxicity)
Human beings are invariably accustomed to the usage of plastics. These plastics pose various health hazards on the human population. According to the Global Industry Analysts in the year 2015, 297.5million tons of plasti...
(part 2, 2/3). Varanasi-Chaukhambha Sanskrit Series Office. P-351. 17. Inderbir Singh, G.P Pal (2013). Edited Human Embryology. 9th Edition. MacMillan Publishers. P-11. 18. T.W Sadler (2012). Edited Langmans Medical Embryology. 12th Edition.Lippincott Williams & Wilkins. P118. 19. T.W Sadler (2012). Edited Langmans Medical Embryology. 12th Edition.Lippincott Williams & Wilkins. P180.
Ancient Indian surgeon, Acharya Sushruta, described in Sushruta samhita over 120 surgical instruments, 300 surgical procedures, classifies human surgery in 8 categories, and describes various surgical procedures viz. abd...
A Conceptual Study on Apasmara (Epilepsy) and its Management with Ayurveda
Today Apasmara (Epilepsy) is a major psychiatric problem worldwide. Numbers of patients are increasing day by day due to the incensement of unrecognized wound, cesarean delivery, mental stress & strain. Infectious diseas...