On the mechanism of agglomeration in suspension
Journal Title: Advanced Pharmaceutical Bulletin - Year 2012, Vol 2, Issue 1
Abstract
Purpose: Agglomeration in suspension is a size enlargement method that facilitates operation of solid processing and preserves the solubilization properties of fine particles. A small quantity of binder liquid is added into a suspension of microparticles, directly in the stirred vessel where the precipitation or crystallization took place. This study deals with the evaluation of the effect of agitation time before and after addition of binder liquid on agglomerates properties in order to give some insights into the mechanism of the formation of the agglomerates. Methods: Carbamazepine is used as a model drug and isopropyl acetate is used as binder liquid. The agglomerates characterization includes the particle size, morphology and density. Results: The results showed that, by increasing the agitation time before addition of binder liquid, smaller agglomerates with less density and irregular forms composed of larger crystals were obtained. However, with increasing agitation time after addition of binder liquid the agglomerates size and density increases and morphology improves. Indeed, by continuing agitation along the course of agglomeration the properties of the particles change gradually but substantially. Conclusion: With optimized agitation time before and after addition of binder liquid, spherical and dense agglomerates can be obtained.
Authors and Affiliations
Maryam Maghsoodi, Katayoun Derakhshandeh, Zahra Yari
Keywords
Related Articles
- EP ID EP119943
- DOI 10.5681/apb.2012.004
- Views 118
- Downloads 0
Virulence and Antimicrobial Resistance in Enterococci Isolated from Urinary Tract Infections
Purpose: Urinary tract infection (UTI) is the most common nosocomial infection among hospitalized patients. Meanwhile, most frequent infections involving enterococci affect the urinary tract. The aims of this study were...
Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine
Purpose: In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated. Methods: Acetic acid i...
Hypoglycemic Activity of Fumaria parviflora in Streptozotocin-Induced Diabetic Rats
Purpose: Fumaria parviflora Lam (Fumariaceae) has been used in traditional medicine in the treatment of several diseases such as diabetes. The present work was designed to evaluate the hypoglycaemic effects of methanolic...
Preparation and Evaluation of Tretinoin Microemulsion Based on Pseudo-Ternary Phase Diagram
Purpose: The aim of the present research was to formulate a transparent microemolsion as a topical delivery system for tretinoin for the treatment of acne. Methods: Microemulsion formulations prepared by mixing appropria...
Protective Effect of Ginger on Gentamicin-Induced Apoptosis in Testis of Rats
Purpose: Ginger, the rhizome of Zingiber officinale, is one of the most widely used spices for various foods and as an herbal medicine in Asian countries. It has been shown that ginger has antioxidant power. Gentamicin i...