Osteonecrosis of the Jaw Related to Oral Bisphosphonate Treatment: A Clinical Case
Journal Title: Dentistry – Open Journal - Year 2014, Vol 1, Issue 1
Abstract
Bisphosphonates are inhibitors of osteoclastic activity and hence cause inhibition of bone resorption.1-3 These drugs, which are synthetic analogy of natural pyrophosphate, have proven their effectiveness in the treatment of diverse metabolic bone diseases related to quantitative alterations, as is the case of osteoporosis,4-6 or qualitative ones, as in Paget’s disease.7 The most common way for their administration is orally.5 These anti-resorptive drugs cause an increase of bone mineral density and a quick decrease of fracture risk.8-13 They are also effective in oncology patients (breast cancer, prostate cancer, lung cancer, and multiple myeloma, among others).14-19 Additionally, these medicines reduce the symptoms of bone pathology (bone pain, delay of the first new bone event, reduction in fracture appearance).4,17-19 They are normally administered intravenously. Bisphosphonates have anti-cancer effect alone or in combination with other chemotherapy treatments, as they maximize antineoplastic effects.20 In pediatrics, they are used in the treatment of diseases related to abnormal calcinosis or ectopic bone formation, as is the case of osteogenesis imperfect.
Authors and Affiliations
Irene García-Ávila
Keywords
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- EP ID EP551915
- DOI 10.17140/DOJ-1-105
- Views 169
- Downloads 0
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