Osteosarcopenia: Clinical Perspective
Journal Title: Turkish Journal of Osteoporosis - Year 2020, Vol 26, Issue 2
Abstract
Osteosarcopenia is a geriatric syndrome characterised by the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. This syndrome may lead to falls and fractures, increased morbidity, mortality and disability, and reduced quality of life. The etiopathogenesis of osteosarcopenia is multifactorial; mechanical, biochemical, genetic and lifestyle factors all play important roles. Its prevalence has been reported between 5% and 37%. The varied prevalence is likely due to the heterogeneous populations or non-unified diagnostic criteria for this syndrome. Osteosarcopenia can be diagnosed by detailed clinical assessment (e.g. screening and risk calculation tools, grip strength, physical performance tests), laboratory tests and imaging methods. Dual-energy X-ray absorptiometry is the most common method used in measuring bone mineral density for the diagnosis of osteoporosis. The imaging techniques used to detect loss of skeletal muscle mass in sarcopenia are dual-energy X-ray absorptiometry, computed tomography, ultrasonography and magnetic resonance imaging. Treatment options for osteosarcopenia include exercise, nutritional supplements (protein, vitamin D, calcium and creatine), life style modifications and pharmacological therapy. With increasing understanding of the underlying mechanisms of osteosarcopenia, the development of therapeutic agents targeting both muscle and bone has become a new area of investigation. This review summarises the epidemiology, pathophysiology, diagnosis and treatment of osteosarcopenia in the light of the relevant literature.
Authors and Affiliations
Yeşim Gökçe Kutsal, Oya Özdemir, Merih Sarıdoğan, Zafer Günendi, Ayşe Küçükdeveci, Yeşim Kirazlı, Jale Meray
Keywords
Related Articles
- EP ID EP688753
- DOI 10.4274/tod.galenos.2020.65477
- Views 137
- Downloads 0
Frequency of Anaemia in Patients with Musculoskeletal Pain
Objective: This study aimed to determine the frequency of anaemia in patients with musculoskeletal pain who were admitted to our clinic. Materials and Methods: Three hundred and thirty-eight patients with musclosketal p...
Evaluation of Bone Mineral Density in Treatment-naive Patients with Human Immundeficiency Virus Infection
Objective: Human Immundeficiency virus (HIV) infection is a risk factor for low bone mineral density (BMD). International HIV/AIDS guidelines do not recommend BMD screening for every patient. In this study, we aimed to c...
Urinary Incontinence Severity, Depression and Anxiety Relation in Osteoporosis Patients
Objective: The present study aimed to analyze the relation between urinary incontinence (UI) severity and depression, anxiety and quality of life in osteoporosis patients. Materials and Methods: Based on the bone minera...
The Effect of Kinesiotaping on Pain, Functionality and Ultrasound Parameters in Patients with Shoulder Impingement Syndrome: A Randomised Sham-controlled Study
Objective: We investigated the effect of kinesiotaping on pain, functionality and ultrasound parameters in patients with shoulder impingement syndrome (SIS). Materials and Methods: Seventy-five patients with SIS were ra...
The Level of Osteoporosis Knowledge and the Related Factors Among Women Who Attended İskenderun Public Education Center Courses
Objective: This study aimed to evaluate the levels of osteoporosis knowledge and self-efficacy and the related factors. Materials and Methods: The study was conducted with 419 women aged between 19 and 60 years who atte...