Outcome of Adjuvant Concurrent Chemo-Radiation in Operated Locally Advanced Rectal Cancer
Journal Title: Journal of Enam Meical College - Year 2015, Vol 5, Issue 3
Abstract
Background: Rectal cancer is one of the most common cancers in Kashmir, India. The clinical course of patients treated with surgery alone has been characterized by a high death rate and also by the pain and disability associated with pelvic recurrence of the tumor. Adjuvant radiation combined with chemotherapy has been studied for prevention of such recurrences. We treat more than 200 rectal cancer patients annually at our center. Most of the patients registered at our center are those who have been already subjected to surgery at the peripheral hospitals. We studied role of 5-fluorouracil (5-FU) and calcium leucovorin concurrently with radiotherapy in Dukes’ stage B2 and C and toxicities thereof in the adjuvant setting. Objective: To assess the outcome of concurrent chemoradiation in operated locally advanced treated cancer patients. Materials and Methods: In operated Dukes’ B2 and C rectal cancer patients, we conducted a prospective non-randomized study comprising of 40 patients between 2012 and 2014. Patients were treated with two hours protracted infusion of calcium leucovorin 500 mg/m2 on day 1 followed by 5-fluorouracil 500 mg/m2 on days 1 to 5 and repeated four weekly for total of six cycles. Radiotherapy of 45 Gray in 20 fractions was delivered concurrently with chemotherapy for first two cycles. Results: Combination of chemotherapy and radiotherapy in a concurrent setting appears to be more efficient in reducing local recurrence rates and improving survival than either modality alone. Toxicities with this schedule were mostly gastrointestinal mucositis, but no treatment interruption was needed. Conclusion: A combination of 5-fluorouracil and radiotherapy can be administered in operated locally advanced rectal cancer patients.
Authors and Affiliations
Syed Arshad Mustafa, M Ismail, Saquib Zaffar, Ghulam Hassan, Waseem Qureshi, SM Kadri
Keywords
Related Articles
- EP ID EP36237
- DOI https://doi.org/10.3329/jemc.v5i3.24744
- Views 316
- Downloads 0
Anemia in Patients with Chronic Obstructive Pulmonary Disease in a Tertiary Care Hospital in Bangladesh
Background: Chronic obstructive pulmonary disease (COPD) is usually associated with polycythemia. It is assumed that systemic inflammatory components of COPD can interfere with erythropoietin and can result in anemia of...
Histological Evidence of Nephroprotective Effect of Ashwagandha (Withania somnifera) Root Extract against Gentamicin Induced Nephrotoxicity in Rats
N0 Abstract
Effect of Oxytocin Injection into Umbilical Vein for Management of Retained Placenta
Background: Retained placenta is one of the causes of post-partum hemorrhage in Bangladesh as it is worldwide. If a retained placenta is left untreated, there is a high risk of maternal morbidity and mortality and it h...
Exercise for the Management of Diabetes Mellitus: A Review of the Evidence
Diabetes mellitus is a public health problem in both developed and developing countries and has increased alarmingly, giving the disease the dimension of an epidemic. The aetiology of diabetes is multifactorial involvi...
Efficacy of Immunodiagnosis of Falciparum Malaria at Different Levels of Parasitemia
Background: Among the several human species of malarial parasites, Plasmodium falciparum can cause severe infection and if left untreated, there may be fatal complications. Early diagnosis and prompt treatment have bee...