Outcome of outborn Babies Admitted with RH Isoimmunization with Mild-to-Moderate Bilirubin Encephalopathy
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 4
Abstract
Objective: The objective of this study was to study the outcome of outborn babies admitted with Rh isoimmunization with acute bilirubin encephalopathy (ABE). Patients and Methods: All babies born outside the institute (outborn) admitted with neonatal hyperbilirubinemia were screened for Rh isoimmunization and ABE. Infants with G6PD deficiency were excluded from the study. Babies were followed till discharge. Number of double volume exchanges, age at the first exchange, time taken for the first exchange, number of blood transfusions, and neurological status at discharge were noted in a structured per forma. Results: A total of 1661 babies were admitted with neonatal jaundice, of which 107 (6.4%) had Rh isoimmunization. 30/107 (28%) babies had mild-to-moderate ABE. All babies underwent double volume exchange transfusion. 20 babies (66%) required the second exchange and only one baby required the third exchange (3.3%). 27 babies (90%) were discharged, of which 20 (74.1%) had intact neurological outcome. 2 (6.7%) babies died due to severe sepsis and 1 (3.3%) left against medical advice. Overall, intact neurological outcome was seen in 66.6% (assuming case of worst case scenario) Conclusion: The incidence of Rh isoimmunization and ABE is still high in our population. These babies require multiple exchange transfusion during admission. The outcome of the babies in ABE can be improved with prompt intervention.
Authors and Affiliations
Anuj Bhatti, Mohd Razzaq
Keywords
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