Ox LDL and its Correlation with HbA1C in Newly Diagnosed T2DM Patients
Journal Title: Harsukh Educational Charitable Society International Journal of Community Health and Medical Research - Year 2018, Vol 4, Issue 3
Abstract
Background: Routine lipid profile fails to explain morbidity and mortality due to cardiovascular complications of Type 2 Diabetes Mellitus (T2DM) and its need of hour to find statistically and metabolically better parameter to assess risk of cardiovascular diseases (CVD) in T2DM. Aims and Objectives: To evaluate values of oxidized Low Density Lipoproteins (ox LDL) in T2DM and find its correlation with glycated hemoglobin (HbA1C). Materials and Methods: 80 newly diagnosed T2DM patients and equal number of age and gender matched healthy individuals were included in the study. Ox LDL along with routine lipid profile, fasting and post prandial blood sugar (FBG & PPBG)) and HbA1c were estimated in all subjects. Results: The values of FBG, PPBG, triglycerides (TG), total cholesterol (TC), low density lipoproteins(LDL), very low density lipoproteins(VLDL), ox LDL and HbA1c were significantly (p<0.001) higher in newly diagnosed diabetic cases as compared to controls. In newly diagnosed T2DM cases, HbA1c had strong positive correlation with TG, TC, LDL, VLDL, oxLDL (r=0.895, r=0.921, r=0.881, r=0.895, r=0.788, respectively) and a strong negative correlation with HDL (r=-0.578). Conclusions: ox LDL shows a strong correlation with HbA1C and is metabolically a better parameter than routine lipid profile. In our study oxLDL is significantly increased in newly diagnosed T2DM patients and its increased levels are proven risk factor of CVD in T2DM patients. We concluded that ox LDL is a promising risk marker for atherosclerosis. It can help in the prompt and early detection of CVD in T2DM patients.
Authors and Affiliations
Gaurav Kumar Bansal, Sanjeev Kumar Bansal, Poonam Mahla, PK Dandona, Busi Karunanand
Keywords
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