Oxidative stress and Antioxidant status in Ghanaians with Type 2 Diabetes Mellitus
Journal Title: International Journal of Medical and Health Sciences - Year 2014, Vol 3, Issue 4
Abstract
An imbalance between reactive oxygen species production and antioxidant scavenging has been implicated in type 2 Diabetes Mellitus (DM). Reports indicate that several complications of Diabetes Mellitus results from increased activity of free radicals and accumulation of lipid peroxidation products leading to oxidative stress. The study aimed at investigating levels of Malondialdehyde, Glutathione Peroxidase and Superoxide Dismutase in type 2 Diabetic subjects. One hundred type 2 Diabetes Mellitus subjects and one hundred Non-Diabetic controls were included in this study. Fasting venous blood sample was obtained for the analysis of glucose, glycated hemoglobin, lipid profile, Malondialdehyde, Superoxide Dismutase and Glutathione Peroxidase. Diabetic subjects had significantly higher total cholesterol (6.8±1.2 Vs 4.3±0.7mmol/L), triglyceride (1.3±0.4 Vs 1.0±0.3mmol/L), LDL-cholesterol (4.0±1.5 Vs 2.7±0.6mmol/L), serum Malondialdehyde (4.40±1.96 Vs 2.75±1.05µM) compared to controls. However, HDL-cholesterol (1.4±0.5 Vs 1.6±0.1mmol/L), Superoxide Dismutase (3.81±1.64 Vs 10.4±2.55 U/Ml) and Glutathione Peroxidase (130.0±16.8 Vs 174.8±36.1 U/L) activities were significantly reduced in type 2 Diabetic subjects when compared with controls. Superoxide Dismutase and Glutathione Peroxidase were found to be decreased in type 2 Diabetes Mellitus patients due to increased oxidative stress.
Authors and Affiliations
H. Asare-Anane, Emmanuel . K. Ofori, P. Ngissah, Seth . D. Amanquah, R. H. Asmah
Keywords
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