OXIDATIVE STRESS IN PRE-ECLAMPSIA- A STUDY ON CORRELATION BETWEEN MALONDIALDEHYDE AND LIPID PROFILE FROM MATERNAL AND CORD BLOOD
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 82
Abstract
BACKGROUND Pre-eclampsia is a complex multisystem disorder that occurs during pregnancy as a complication. This is associated with hypertension and the blood pressure is either 140/90 mmHg or more and in addition proteinuria. Incidence of pre-eclampsia occurs between 3% and 10% of pregnancies and the pathogenic characteristics are vasospasm, increased peripheral vascular resistance and reduced organ perfusion. Exact cause of pre-eclampsia is still unexplored, but improper placentation is an important factor, and among other causes generation of free radicals leading to oxidative stress is thought to be the prime cause. Oxidative stress results in damage to the biomolecules with generation of reactive oxygen species, and since the lipid peroxidation products play major roles in generation of free radicals our objective was to establish a correlation between lipid profile and an important lipid peroxidation intermediate like malondialdehyde in maternal and cord blood of women with preeclampsia. MATERIALS AND METHODS We included 50 pre-eclamptic women for this descriptive comparative study. For controls, 20 healthy pregnant women were selected. Sample size was selected conveniently. Immediately after delivery, maternal and cord blood samples were collected from all the participants, and after serum separation estimation of serum lipid profile and MDA were performed. The results were compared. RESULTS We observed a direct relationship between serum triglycerides and MDA in patients with pre-eclampsia. Hypertriglyceridaemia and high MDA level have been observed in pre-eclampsia. CONCLUSION Altered lipid profile may be responsible for increased oxidative stress that results due to increased lipid peroxidation in preeclampsia and this might be responsible for other complications during pregnancy.
Authors and Affiliations
Rina Kumari, Gajendra Kumar, Niru Chhetri, Rajni Rajni, Gorachand Bhattacharya
Keywords
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- EP ID EP276080
- DOI 10.14260/jemds/2017/1248
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