OXIDATIVE STRESS STATUS IN PATIENTS WITH TYPE2 DIABETES MELLITUS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 6
Abstract
Background: Oxidative stress due to chronic hyperglycemia has been implicated in the pathogenesis of type 2 diabetes and its complications. Objectives: To estimate the levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation marker i.e. malondialdehyde (MDA) in type 2 DM patients with and without complications i.e., neuropathy, nephropathy and cardiovascular diseases compared to normal subjects. To access the association between oxidative stress and diabetes mellitus and development of its complication. Materials and methods: Plasma levels of SOD, CAT and MDA were estimated in 50 Control and 140 diabetic patients divided into: DWC group consisted of diabetic patients without complications, CAD group consisted of patients with coronary artery disease, DN group consisted of patients with diabetic nephropathy, DNe group consisted of patients with diabetic neuropathy. Spectrophotometry and enzyme-linked immunosorbent assay (ELISA) techniques have been applied for determination of MDA, CAT and SOD respectively. Results: comparing the levels of SOD and CAT in all groups, it was observed that the lowest concentration was in CAD, DN, DNe groups followed by DWC and control groups. Oxidative stress was found increased in CAD, DN, DNe groups as compared to DWC and control groups since, the highest concentration of MDA levels were observed in these groups. A significant inverse correlation was observed of HbA1c, insulin and MDA with SOD, CAT in all diabetic groups. And a significant direct correlation between HbA1C and MDA was also observed in all diabetic groups. Conclusion: The present study confirms susceptibility of diabetic patients to oxidative stress and that poor glycaemic control is associated with free radical-mediated lipid peroxidation. The present study arrived to the conclusion that hyperglycemia and oxidative stress present a high risk for development of diabetic complications and need early intervention.
Authors and Affiliations
Selma. M Osman. M. Yousif, Mohammed S. M. Abdalla, E. M. A. Elmahdi, Manal. Mohammed. Ramadan.
Keywords
Related Articles
- EP ID EP341354
- DOI 10.21474/IJAR01/7231
- Views 74
- Downloads 0
CHEMOPREVENTION OF LUNG CARCINOGENESIS IN STRAIN BALB/C MICE WITH POLYPHENOLS OF MAHKOTA DEWA (PHALERIA MACROCARPA) FROM INDONESIAN HERBAL.
Backgroud and objective: Polyphenols of Mahkota Dewa (Phaleria macrocarpa) has potential as anticancer that is expected to inhibit lung carcinogenesis, but it has not been widely studied. This study aims to prove the rol...
QUALITATIVE AND QUANTITATIVE ANALYSIS OF APICAL MICROLEAKAGE OF DIFFERENT ENDODONTIC SEALERS.
Purpose: The purpose of the study was to compare the apical microleakage of five root canal sealers using qualitative dye penetration method and quantitative dye extraction method. Materials & Methods: Fifty single roote...
TRAUMATIC ANEURYSMS AND ARTERIOVENOUS FISTULA.
Posttraumatic pseudoaneurysms and arteriovenous fistula are rarely observed(1) where time from trauma to diagnosis varies from hours to years. Because of the imminent clinical course, early operation is usually indicated...
RECONSTRUCTION OF PENAL SANCTIONSAGAINST CORRUPTION(A DIGNIFIED JUSTICE PERSPECTIVE).
Barriers to the development, peace and prosperity of the Republic of Indonesia as the consequence of ramphant criminal act of corruption has spread widely in the community and the nation as a whole. Worse than that, acco...
WOMEN/FOSTER MOTHERS WHO FED THE HOLY PROPHET (P.B.U.H).
The Prophet of Islam, Hazrat Muhammad (PBUH) is the central personality of Islam. Each and every aspect of his life is of utmost importance to Muslims and thus is studied in detail by researchers and scholars of all time...