PARKINSON’S DISEASE: A PHYTOCHEMICAL APPROACH
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 2
Abstract
Parkinson’s disease (PD) is a progressive and age-dependent neurodegenerative movement disorder. It is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNPC) region of the midbrain that culminates in the major clinical symptoms of PD. The etiology of the neuronal cell death is still unclear, but mitochondrial dysfunction, oxidative stress and subsequent apoptotic cell death have been considered as underlying mechanisms of dopaminergic cell death. Although the current therapeutics applied for this disorder produce a symptomatic relief, treatment strategies for slowing down the disease progression are yet to be developed. Under these circumstances with no causal therapy is yet available, biomedical researchers are turning their interests towards exploiting the wealth of traditional knowledge on medicinal plants. This review presents the current scientific information on the neuroprotective potential of traditional plants like Mucuna pruriens, Gingko biloba, Panax ginseng, Centella asiatica, Bacopa monnieri, Withania somnifera, Scutellaria baicalensis and some popular phytochemical constituents. This information may contribute largely for developing better protective neurotherapeutics for Parkinson’s disease in near future.
Authors and Affiliations
S. Divya1 , S. Kavimani1 , S. Sudha Rani2 , S. Subashree , Syam Praveen Kumar2 , G. Mahalakshmi , T. Nirmala1 , R. Samundeswari1 , D. Sivassoupramanian1
Keywords
Related Articles
- EP ID EP101134
- DOI -
- Views 168
- Downloads 0
A MINE OF MEDICINAL USES: OCIMUM SANCTUM, THE HOLY BASIL
The medicinal plants are rich in secondary metabolites, which are potential sources of drugs and essential oils of therapeutic importance. One such plant of interest is Ocimum sanctum (Lamiaceae). Traditionally used sinc...
SPECTROPHOTOMETRIC ESTIMATION OF ZIDOVUDINE IN BULK AND TABLET DOSAGE FORM
A simple, rapid and economical spectrophotometric was developed for the estimation of zidovudine in bulk and tablet dosage forms. The results obtained were found to be good and sensitive. The method was validated and was...
DEVELOPMENT AND INVITRO CHARACTERIZATION OF PACLITAXEL SUSTAINED RELEASE MICROSPHERS
The objective of the present work was to formulate and evaluate sustained release paclitaxel microspheres for treating breast, ovarian and colon cancer effectively. Sustained release paclitaxel microspheres for minimum f...
A RIEVEW OF COMPARATIVE STUDY OF RICE BRAN OIL AND RICE BRAN WAX
Rice bran wax is a natural vegetable wax and is a value added by product of Rice bran oil refineries. According to the Indian Council of Medical Research. Rice bran oil has an almost balanced fatty acid composition that...
NANOPARTICLES A NOVEL APPROACH-A REVIEW
Poor aqueous solubility represents a major hurdle in achieving adequate oral bioavailability for a large percentage of drug compounds in drug development nowadays. Nanosizing refers to the reduction of the active pharmac...