Pathophysiological aspects of the pancreas function in rats with monosodium glutamate-induced obesity
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 4
Abstract
Our study demonstrates that neonatal treatment with monosodium glutamate (MSG) leads to the development of visceral obesity in adult rats. In rats’ pancreas of both sexes massive edema and inflammation were found, which are characteristic of acute pancreatitis. Marked intralobular and perivascular lipomatosis was also found. There was also marked leukocyte infiltration in rats with MSG-induced obesity. Morphometric analysis confirmed pathological changes in pancreatic tissue. The level of blood amylase, lipase and pancreatic amylase was increased by 92% (p<0.001), 312% (p<0.001) and 162% (p<0.001). So, neonatal treatment with MSG leads to the development of pancreatitis in adulthood of rats. We concluded that the development of pancreatitis in rats with MSG-induced obesity is the result of increase of synthetic and secretory processes in pancreatic cells.
Authors and Affiliations
Ivan Leschenko, Victor Shevchuk, Oleksandr Savcheniuk, Tetyana Falalyeyeva
Keywords
Related Articles
- EP ID EP88916
- DOI -
- Views 135
- Downloads 0
Omentin - a new adipokine with many roles to play[sub][/sub]
DOI: 10.1515/cipms-2015-0067 Adipose tissue is at a point of high interest in medical research, not only as an energy depot, but also because it secretes nearly more than 600 cytokines. These are termed‚ adipokines’. Hu...
The use of alloplastic biomaterials in the surgical treatment of aggressive periodontitis – a case report
Periodontitis is a commonly encountered disease of the mouth, in man. This inflammatory process results in the impairment of the connective tissue attachment and alveolar bone resorption. Guided tissue regeneration, whic...
Back pain and physical activity: Students of the Medical University of Lublin
At the present time, back pain and posture problems affect a growing number of young people. This is probably due to a changing lifestyle which has led to less physical activity. The aims of our study were to evaluate th...
In vitro study: binding of 99mTc-DPD to synthetic amyloid fibrils
This paper is an report of the investigation of the in vitro binding of 99mTc-DPD for synthetic amyloid fibrils used for the diagnosis of cardiac amyloidosis (CA), as compared with the use of 99mTc-HMDP and 99mTc-PPI. It...
The influence of selected demographic and socioeconomic factors on patient’s decision-making about the treatment of missing teet
The research aimed at assessment of the influence of selected demographic and socioeconomic factors on patient's decision-making about the treatment of missing teeth using the implants. The survey was conducted among 46...