Pd-1/Pd-L Pathway: Its Preclinical Rationale and Clinical Application in Lymphoid Neoplasms
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 1
Abstract
The PD-1/PD-L1 pathway plays an important role in mediating immune tolerance in physiological stateand is an important mechanism by which malignancies can evade the host immune response. PD-1 inhibitors may be particularly attractive for hematologic malignancies because the activation of adoptive immunity has been proven effective in the form of allogeneic stem cell transplantation. Clinical trials of anti-PD-1 monoclonal antibodies have demonstrated promising results in lymphoma patients with advanced disease. PD-1 Is a 55-kDa type I transmembrane protein that belongs to the immunoglobulin super family. PD-1 exists as a monomer on the cell surface of activated T cells, B cells, natural killer T cells, monocytes, and some dendritic cell subsets. PD-1 delivers a co-inhibitory signal upon binding to either of its two ligands, PD-L1 or PD-L2 [1]. PD-L genes have been shown to be key targets of structural amplification of chromosome 9p24.1 [2]. PD-L1 and PD-L2expression PD-L2 expression is mostly restricted to hematopoietic cells while PD-L1 is expressed on hematopoietic cells and peripheral tissues as well as many malignant cells, and [2] immune regulatory cells of the tumor microenvironment, such as myeloid-derived suppressor cells that may work in concert with malignant cells [3].
Authors and Affiliations
Nahla A M Hamed
Keywords
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- EP ID EP567602
- DOI 10.26717/BJSTR.2017.01.000159
- Views 158
- Downloads 0
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