PECULIARITIES OF OXAZOLE HERBICIDES MODE OF ACTION ON WARM-BLOODED AND HUMAN ORGANISM
Journal Title: Ukrainian Scientific Medical Youth Journal / Український Науково-Медичний Молодіжний Журнал - Year 2012, Vol 68, Issue 2
Abstract
It was established that the main mechanisms of action of oxazole herbicides are inhibition of 4-hydroxyphenylpyruvatedioxygenase with tyrosinemia developing and alteration of thyroid hormone level as a result of hepatic enzymes induction. The main target organs of topramezon and isoxaflutole action are eyes, liver and thyroid gland. It was proved that the most adequate model for tyrosinemia’s effects extrapolation on human are mice because activity level of their tyrosine aminotransferase is similar to human ones.
Authors and Affiliations
A. Antonenko
Keywords
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