Pelletization as a key tool for oral drug delivery: A review
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
Multiparticulate systems prove to be promising system for oral drug delivery. Pelletization is a process in which fine powders or granules are converted into free flowing semi-spherical units referred as pellets. Pellets are the multiple unit dosage forms which can be formulated in the form of suspensions, capsules or disintegrating tablets. This review outlines manufacturing and evaluation of spherical pellets. The manufacturing techniques include extrusion/spheronization, hotmelt extrusion, layering, globulation, compression, balling, freeze pelletization and cryopelletization. Evaluation of quality of the pellets is discussed with reference to the shape, size distribution, surface morphology, specific surface area, density, friability, tensile strength.
Authors and Affiliations
Af i fa Bathool*, Gowda D. Vi shakant e , Mohammed S. Khan, Vikas K Gupta
Keywords
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