PELLETIZATION TECHNIQUES: A LITERATURE REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
In present times, the pelletization technologies are gaining much attention as they represent an efficient pathway for manufacture of oral drug delivery systems. This is due to the reason that pellets offer many therapeutic, technological as well as biopharmaceutical advantages over the conventional oral dosage forms. Pelletization technique enables the formation of spherical beads or pellets with a mean diameter usually ranging from 0.5-2.0 mm which can be eventually coated for preparation of modified release dosage forms. Pelletization leads to an improvement in flowability, appearance and mixing properties thus avoiding generation of excessive dust and reducing segregation, and, generally, eliminating undesirable properties and improving the physical and chemical properties of fine powders. Pellets are produced by various techniques, such as, extrusion/ spheronization, layering, cryopelletization, freeze pelletization, spray congealing, spray drying and compression. Amongst various techniques, Extrusion/Spheronization technique is the most widely utilized technique due to its high efficiency and simple and fast processing. The aim of this paper is to review some general aspects about pellets and pelletization and some common techniques being utilized in the pharmaceutical industry.
Authors and Affiliations
Supriya Punia , Rajni Bala , A. C. Rana
Keywords
Related Articles
- EP ID EP129986
- DOI -
- Views 110
- Downloads 0
PRACTICING HOSPITAL PHARMACISTS MENTORING PHARMACY STUDENTS IN CLINICAL PHARMACY: AN EXPERIENCE FROM DOW UNIVERSITY OF HEALTH SCIENCES (DUHS) PAKISTAN
Pharmacy education has been an important and integral part of the education system of a country. Pharmacy education in Pakistan has grown significantly through the ages and there are quite a few number of pharmacy school...
NUTRITIONAL AND ANTIOXIDANT EVALUATION OF EARTHWORM POWDER (Eudrillus euginae)
Studies have been made to understand the nutritional, aminoacids and antioxidant concentrations in the dried powder of Eudrillus euginae, an African soil dweller. The nutritional factors such as carbohydrate, glucose, to...
DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF COLCHICINE IN PHOSPHATE BUFFER SALINE pH 6.4
The present investigation explores a method to analyze colchicine in phosphate buffer saline pH 6.4. Based on the spectrophotometric characteristics of colchicine, λmax selected was 353.8 nm. Analytical parameters valid...
ANTHELMINTIC ACTIVITY OF METHANOLIC LEAF EXTRACT OF SOPHORA INTERRUPTA
Crude methanolic extracts of leaves of Sophora interrupta (Fabaceae) were evaluated for in vitro anthelmintic activity on the Indian adult earthworms Pheritima posthuma. Albendazole was used as a standard drug to compare...
EVALUATION OF ANTIOXIDANT POTENTIAL AND FOURIER TRANSFORM INFRARED SPECTROSCOPY ANALYSIS OF ANANUS COMOSUS (L.) MERRILL PEEL
Ananas comosus (L.) Merrill is belonging to the family Bromeliaceae which act as an anti-inflammatory, antitumor effect. The present study is aimed to appraise the antioxidant potential and Fourier transform infrared spe...