Pelvic Actinomycosis Masquerading as Malignancy
Journal Title: Gynecology and Obstetrics Research – Open Journal - Year 2016, Vol 3, Issue 2
Abstract
Pelvic actinomycosis is a chronic granulomatous suppurative disease caused by Actinomyces israeli. The opportunistic anaerobic bacterium Actinomycosis israeli is a normal part of the human flora in the oropharynx, gastrointestinal and genital tract.1 More than 50% of actinomycosis infections occur in the craniofacial region. Pelvic infection accounts for 20% of human cases.2 Abdominal-pelvic actinomycosis is often mistaken for other conditions, presenting a pre-operative diagnostic challenge. The infection mimics ovarian tumors and tuberculosis and is diagnosed only after surgery in most of the cases. Actinomycosis secrete proteolytic enzymes, disrupt tissue planes and compress surrounding tissues which makes their presentation closer to a malignant process.3 Slow growing nature of actinomyces, non-specific clinical presentation and extensive spread before the diagnosis is made often pose a clinical challenge. Owing to slow growing nature and chronic inflammatory process, pre-operative diagnosis is difficult and is often made retrospectively after surgical debulking. Infection is rare in infants and children. Many cases are found in women using intra-uterine contraceptive device (IUCD). Actinomycosis is 3 times more common in men than women. Alcoholism, intravenous drug abuse, peptic ulcer, and biliary tract disease are risk factors for actinomycosis.4 It is most commonly found in regions of low socio-economic status and poor hygiene.5 We review a case of pelvic actinomycosis that was managed at the Obstetric and Gynecology Department of K. J. Somaiya Hospital, Mumbai, India.
Authors and Affiliations
Aakash Pandita
Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries
Objective: This study was designed to assess the effects of maternal nifedipine administration on blood flow resistance in uterine, umbilical and fetal middle cerebral arteries by evaluating resistance index (RI) and pul...
Female Genital Schistosomiasis: A Neglected Tropical Disease
Female genital schistosomiasis is a neglected tropical disease. Few clinicians consider it in their differential diagnosis. Yet this disease affects hundreds of millions of people. Hundreds of thousands of them actually...
Gynecologic Cancer Research at a Crossroads
Gynecologic cancer research is currently at a crossroads. Recent changes in the NCI’s approach to clinical cancer research have resulted in a complex makeover of the federal clinical research community. This was prompted...
High-Throughput Next Generation Sequencing: Applications in Reproductive Diagnosis and Research
The genetic information contained within a cell is transferred through the process of transcription of genes within a genome to produce messenger RNAs (mRNAs) and translation of mRNAs to synthesize proteins. The central...
The Use of Localised Vaginal Drug Delivery as Part of a Neoadjuvant Chemotherapy Strategy in the Treatment of Cervical Cancer
Cervical cancer is the third most prevalent cancer in women globally, with 529,000 diagnosis and 275,000 deaths each year. It is especially prevalent in developing countries where approximately 85% of cases arise due to...