PEMPHIGUS VULGARIS: AN INSIGHT ON CONVENTIONAL AND EMERGING TREATMENT MODALITIES 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3

Abstract

According to Sir William Osler, Mouth is the mirror of the body which reflects systemic diseases. The oral mucosa may be affected by a variety of muco-cutaneous diseases and oral lesions may occur first or very early in several muco-cutaneous disorders. Pemphigus is a group of potentially life threatening, chronic auto immune disorder characterized by epithelial blistering affecting muco-cutaneous surfaces. Autoantibodies in pemphigus vulgaris are directed against desmoglein in epithelial desmosomes, and the immune deposits result in intra-epithelial splitting (acantholysis). Oral lesions in the form of blisters and erosions are the first to manifest, and diagnosis is made by positive nikolsky’s sign, coupled with characterstic histopathology and immunofluorescent features. Corticosteroids form the mainline of treatment, but adjuvant and newer therapies are also been used at an increasing rates. This article deals about the etio-pathogenesis, clinical characterstics, diagnosis and treatment strategies for pemphigus vulgaris. 

Authors and Affiliations

Shamimul Hasan, Nabeel Khan, Osama Sherwani, Vasundhara Bhatt, Himangi Srivastava

Keywords

Related Articles

DETERMINE THE EFFICACY OF CARBOPLATIN WITH VITAMIN C IN DALTON'S LYMPHOMA TUMOR IN MICE MODEL  

Carboplatin, a platinum-containing anticancer drug treatment caused a significant increase in the life span of ascites Dalton’s lymphoma tumor bearing mice. However, as compared to carboplatin alone, combination treatmen...

PRODUCTION, PURIFICATION AND FUNCTIONALIZATION OF CARBON NANOTUBES FOR MEDICAL APPLICATIONS 

Carbon nanotubes (CNTs) are needle-like potential carriers of bioactive including drug, genes and proteins. This review considers several techniques that have been developed for fabricating, purifying and functionalizing...

ROOT AND ROOT CANAL MORPHOLOGY AND ITS VARIATION OF THE HUMAN MANDIBULAR CANINE: A LITERATURE REVIEW  

The objective was to review the literature of the root and root canal morphology of the human Mandibular canine. Published studies cite the anatomy and morphology of the mandibular canine tooth. Individual case reports o...

FORMULATION AND EVALUATION OF DENTAL FILM FOR PERIODONTITIS 

Controlled release local drug delivery systems offer advantages compared to systemic dosage forms for periodontitis. The objective of this research was to design and evaluate sustained release dental films containing lom...

ISOLATION AND HPTLC ESTIMATION OF AESCULIN FROM OXYSTELMA ESCULENTUM  

Oxystelma esculentum R. Br. (Family: Asclepiadaceae) is a perennial twiner growing in water-logged areas of the Indian sub-continent. It is used traditionally as diuretic, laxative and anti-ulcer. The present work deals...

Download PDF file
  • EP ID EP161718
  • DOI 10.7897/2230-8407.04303
  • Views 125
  • Downloads 0

How To Cite

Shamimul Hasan, Nabeel Khan, Osama Sherwani, Vasundhara Bhatt, Himangi Srivastava (2013). PEMPHIGUS VULGARIS: AN INSIGHT ON CONVENTIONAL AND EMERGING TREATMENT MODALITIES . International Research Journal of Pharmacy (IRJP), 4(3), 8-12. https://www.europub.co.uk/articles/-A-161718