PEMPHIGUS VULGARIS: AN INSIGHT ON CONVENTIONAL AND EMERGING TREATMENT MODALITIES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
According to Sir William Osler, Mouth is the mirror of the body which reflects systemic diseases. The oral mucosa may be affected by a variety of muco-cutaneous diseases and oral lesions may occur first or very early in several muco-cutaneous disorders. Pemphigus is a group of potentially life threatening, chronic auto immune disorder characterized by epithelial blistering affecting muco-cutaneous surfaces. Autoantibodies in pemphigus vulgaris are directed against desmoglein in epithelial desmosomes, and the immune deposits result in intra-epithelial splitting (acantholysis). Oral lesions in the form of blisters and erosions are the first to manifest, and diagnosis is made by positive nikolsky’s sign, coupled with characterstic histopathology and immunofluorescent features. Corticosteroids form the mainline of treatment, but adjuvant and newer therapies are also been used at an increasing rates. This article deals about the etio-pathogenesis, clinical characterstics, diagnosis and treatment strategies for pemphigus vulgaris.
Authors and Affiliations
Shamimul Hasan, Nabeel Khan, Osama Sherwani, Vasundhara Bhatt, Himangi Srivastava
Keywords
Related Articles
- EP ID EP161718
- DOI 10.7897/2230-8407.04303
- Views 123
- Downloads 0
FORMULATION OF KETOCONAZOLE OPHTHALMIC OINTMENT USING COW GHEE AS A BASE AND PENETRATION ENHANCER
The present work is concerned with the study of cow ghee as penetration enhancer in ketoconazole ophthalmic ointment as an ointment base with respect to conventional ointment base. Ophthalmic ointment was prepared with 1...
FORMULATION DEVELOPMENT OF IRBESARTAN (POORLY WATER-SOLUBLE DRUG) IMMEDIATE RELEASE TABLETS
The aim of the present study is to increase the solubility of poorly water soluble drug Irbesartan by using surfactants and formulating into immediate release tablets by using super disintegrants. Surfactants such as sod...
ETHNOBOTANICAL UTILIZATION OF SOME MEDICINAL PLANTS BY BODO PEOPLE OF MANAS BIOSPHERE RESERVE IN THE TREATMENT OF MALARIA
Malaria is a parasitic disease caused by Plasmodium falciparum and P. vivax, transmitted by a female Anopheles mosquito from the blood of an infected person to a healthy person. Malaria is one of the major problem in No...
REVIEW / PHARMACOLOGICAL ACTIVITY OF PLATYCLADUS ORIEANTALIS
Platycladus orientalis, also known as Chinese Arborvitae or Biota. It is native to northwestern China and widely naturalized elsewhere in Asia east to Korea and Japan, south to northern India, and west to northern Iran....
ETHNO MEDICINAL AND THERAPEUTIC POTENTIAL OF SIDA ACUTA BURM.F.
Sida is one of ethnomedicinally important genus of plants. The plants from genus Sida are used in India over 2000 years. The most medicinally important species of Sida like, Sida acuta, Sida cordifolia, S. rhombifolia, S...