Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken
Journal Title: Journal of Animal and Feed Sciences - Year 2011, Vol 20, Issue 1
Abstract
It is known that centrally injected ghrelin is an anorexigenic peptide in chicken. Its activity is not mediated by NPY/AgRP - producing neurons but through the corticosterone releasing hormone (CRH) - expressing neurons in hypothalamus which activate the hypothalamo-pituitary-adrenal (HPA) axis inducing an increase in plasma corticosterone levels. However, controversial results of peripheral ghrelin effect on appetite have been reported. Thus, the influence of intraperitonealinjected ghrelin on the activity of the HPA axis in Cobb broiler chickens was examined. In addition, the effect of glucocorticoids antagonist (RU486) on the ghrelin activity was also investigated. The intraperitoneal co-injection of CRH-receptor antagonist, astressin, partially attenuated ghrelininduced anorexia and corticosterone release. Co-administration of RU486 significantly enhanced the inhibitory effect of ghrelin on feed intake in 7-day- old broiler chickens. These results indicate that the peripheral ghrelin - induced anorexia is caused by the stimulation of HPA axis in chickens.
Authors and Affiliations
E. Ocłoń, M. Pietras
Keywords
Related Articles
- EP ID EP74722
- DOI -
- Views 133
- Downloads 0
The quality of different mono- and dicalcium phosphates estimated on the basis of their crystalline phases, chemical composition, solubility, and biological parameters of broiler chickens
The quality of five commercial monocalcium phosphates (MCP) and dicalcium phosphates with natural admixtures of hydrated and dehydrated forms was assessed on the basis of their crystalline phases determined by roentgenog...
Effects of supplementing a mixed diet with echium (Echium plantagineum) oil on methanogenesis in a rumen simulation system
The rumen simulation technique (RUSITEC) was used to evaluate the effect of two levels of echium (Echium plantagineum) oil (EO) on methano-genesis. Treatments comprised: control (commercial total mixed ration for lactati...
Modeling lactation curves of Polish Holstein-Friesian cows. Part II: Prediction of 305-d lactation milk, fat and protein yields
The objective of the study was to compare five lactation curve models, Ali and Schaeffer, Guo, Wilmink, and third- and fourth-order normalized Legendre polynomials, for their ability to reliably predict 305-d lactation y...
The effect of breed and feeding level on carcass composition, fatty acid profile and expression of genes encoding enzymes involved in fat metabolism in two muscles of pigs fed a diet enriched in n-3 fatty acids. A preliminary study
The experiment was performed according to a 2 x 2 factorial design with breed and level of nutrition as factors affecting fat metabolism in pigs. Two groups of gilts, each comprising 4 Polish Large White (PLW) and 4 Synt...
Utilization of microbial selenium collected from the rumen of sheep
The bioavailability of incorporated Se from bacteria and protozoa collected from rumen of sheep was investigated using female Wistar rats to simulate the lower digestive tract of a ruminant. The rats were fed diets suppl...