PHARMACEUTICAL TASTE MASKING TECHNOLOGIES OF BITTER DRUGS: A CONCISE REVIEW
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 5
Abstract
Taste refers to a perception arising from the stimulation of taste buds present on the surface of the tongue. Humans can distinguish among five components of taste: sourness, saltiness, sweetness, bitterness, and umami (savory). Taste is an important parameter in case of drugs administering orally and is a critical factor to be considered while formulating orodispersible, melt in mouth, buccal tablet and other formulations which comes in contact with taste buds. Bitter and unpalatable taste is a major problem of certain drugs in formulations. Masking the bitter taste of drugs is a potential tool for the improvement of patient compliance which in turn decides the commercial success of the product. According to the year 2003 survey of pediatricians by the American Association of Pediatrics, unpleasant taste was the biggest barrier for completing treatment in pediatrics. The field of taste masking of active pharmaceutical ingredients (API) has been continuously evolving with varied technologies and new excipients. Two approaches are commonly utilized to overcome the bad taste of the drug. The first includes reduction of drug solubility in the saliva and second approach is to alter the ability of the drug to interact with taste receptor. Various methods are available to mask the undesirable taste of the drugs. Some of them are coating of drug particles, by formation of inclusion complexes, molecular complexes of drugs with other chemicals, solid dispersions, melting method, micro encapsulation, prodrugs, mass extrusion methods and ion exchange resins.
Authors and Affiliations
Patel Chirag J*| Editor-in-Chief, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Patan, Gujarat, India-384265., Prof. Satyanand Tyagi| President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074., Mangukia Dhruv| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Mangukia Ishita| Department of Pharmaceutics, Parul Institute of Pharmacy, Vadodara, Gujarat, India-391760., Anil Kumar Gupta| Jyoti Vidyapeeth women’s University, Jaipur, discipline of Pharmaceutical Science, Jaipur, Rajasthan, India-303007., Mohammed Rageeb Mohammed Usman| Associate Editor, Tyagi Pharmacy Association (TPA) & Assistant Professor, Department of Pharmcognosy, Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India-425107., Jony Mallik| M.Pharmacy Scholar (Department of Pharmacy), Southern University Bangladesh, Department of Pharmacy, 739/A, Mehedibag Road, Chittagong, Bangladesh-4200., Nikhala Shree| Senior Research Fellow (S.R.F), Tamil Nadu Veterinary and Animal Sciences University, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram Milk Colony, Madhavaram, Chennai, Tamil Nadu, India-6000051., Shravan Kumar Paswan| M. Pharmacy Scholar (Department of Pharmacology), Advance Institute of Biotech and Paramedical Sciences, Advance Institute of Biotech and Paramedical Sciences, G.T.Road, Naramau, Kanpur, Uttar Pradesh, India-209217.
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