Pharmacogenomics in the treatment of acute lymphoblastic leukemia in children
Journal Title: Medicina Fluminensis - Year 2008, Vol 44, Issue 1
Abstract
Over the past decades, the treatment of acute lymphoblastic leukemia in children has made remarkable progress. Pharmacogenomics of acute leukemias elucidates mechanisms of genetic control of antileukemic effects of chemotherapy and development of drug resistance. The aim of pharmacogenomic studies, related to the treatment of pediatric acute lymphoblastic leukemias, is to identify genes responsible for drug efficacy and toxicity, matched with the genetic makeup of every individual child. Pharmacogenomics offers the reasonable promise of therapeutic optimization and individualization, and further improvement of treatment outcome in childhood lymphoblastic leukemia.
Authors and Affiliations
Jelena Roganović
Keywords
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