Pharmacological Effect of α-Glucosidase Inhibitor Voglibose in a Novel Obese Diabetic Model
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 23
Abstract
Aim: This study was conducted to investigate the preventive or therapeutic effect of α-glucosidase inhibitor voglibose in a new model rat, Spontaneously Diabetic Torii-Leprfa (SDT fatty) rat, which is a novel type 2 diabetic rat showing obesity, hyperglycemia and hyperlipidemia from a young age. Place and Duration of Study: Niigata University and JT Central Pharmaceutical Research Institute, between January and August 2011. Methodology: The present study was designed to the preventive and therapeutic effect of voglibose by administering (0.3, 1 mg/kg) voglibose as a dietary admixture to SDT fatty rats from 5 to 11 and 14 to 20 weeks of age, respectively. Results: In the examination of preventive effect, the obtained biochemical results show that voglibose decrease glucose level significantly in dose-dependent manner within 5-11 weeks of age. In voglibose-treated rats at 11 weeks of age, the histopathological pancreatic changes, such as vacuolation and irregular boundaries in islets, were improved. On the other hand, in the examination of therapeutic effect, voglibose improved the hyperglycemia only at a dose of 1 mg/kg within 16-20 weeks of age. Conclusion: Voglibose showed both preventive and therapeutic effects for diabetes in female SDT fatty rats. The SDT fatty rat is a useful model for development of anti-diabetic agents.
Authors and Affiliations
T. Ohta, Y. Kemmochi, K. Miyajima, M. Shinohara
Keywords
Related Articles
- EP ID EP344453
- DOI 10.9734/BJPR/2014/13553
- Views 97
- Downloads 0
GCMS Analysis of Leaf and Salt Stress Callus of Eggplant (Solanum melongena L.)
In the present study, the leaf explant cultured on a MS medium supplemented with BAP (4.44 μM) + NAA (0.98 μM) had the ability to induce more amount of green and friable callus. The 40 days old best grown callus was sub...
Evaluation of the Analgesic Effects of Nigella sativa Ethanolic Extracts on Experimentally Induced Pain in Albino Mice
Background: Analgesic and anti-inflammatory drug abuse has become a major problem in the world due to over-the counter sale of such drugs and these are causing not only gastritis, gastric ulcers, gastro-intestinal tract...
Solid State Characterization of Two Tropical Starches Modified by Pregelatinization and Acetylation: Potential as Excipients in Pharmaceutical Formulations
Aims: To pre-gelatinize, acetylate and characterize Dioscorea dumetorum (bitter yam) and Dioscorea oppositifolia (Chinese yam) starches using solid-state parameters such as differential scanning calorimetry (DSC), X-ray...
Antibiotic Resistance: Challenges and Prospect for Therapy in Developing Countries
The hope raised by the discovery of antibiotics has been marred by the emergence of antibiotic resistance. The major reason for this is the inappropriate use of antibiotics due to a lack of uniform policy and disregard t...
Memory Enhancing Activity of Dendrobium macraei Lindl. in Swiss Albino Mice
Background: Memory is not a single process, but rather a series of interactive processes beginning when we are exposed to new information, which is registered by the brain, encoded, and in the right conditions, stored fo...