PHARMACOLOGICAL SCREENING OF ISOLATED COMPOUND FROM MADHUKA LONGIFOLIA SEEDS GIVES SIGNIFICANT ANALGESIC EFFECT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
The study was carried out to assess the analgesic effect of aqueous and ethanolic extracts of isolated compound from M.longifolia seeds in rats and mice model. All three animal groups were administered the aq. and alc.ext of M.longifolia at a dose of 4 mg to 64 mg/kg body weight. The standard drug diclofenac 5 mg/kg b.w is used in three screening method. The paw licking time, tail withdrawal time and chemical writhings in mice both aq. and alc. extracts of M.longifolia prevents significant dose dependent anti-nociceptive effect. Diclofenac 5 mg/kg failed to alter significantly the antinociceptive effect of 16 to 32 mg of both extracts or the effect on chemical assay.
Authors and Affiliations
Chirantan Chakma
Keywords
Related Articles
- EP ID EP140252
- DOI -
- Views 120
- Downloads 0
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ELETRIPTAN IN ELETRIPTAN HYDROBROMIDE ORALLY DISINTEGRATING TABLETS
A simple, precise, rapid and accurate stability indicating reverse phase high performance liquid chromatography has been developed and validated for the estimation of Eletriptan Hydrobromide in tablet dosage form. Separa...
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF ISOSORBIDE MONONITRATE
The aim of the present study was to formulate and evaluate the mouth dissolving tablets of isosorbide mononitrate. Drug delivery systems are becoming more complex as pharmaceutical scientist acquires better understanding...
AN EFFECTIVE HERBOMINERAL TREATMENT AS AN ADJUVANT THERAPY FOR THE IMPROVEMENT OF QUALITY OF LIFE OF HEPATOCELLULAR CARCINOMA (HCC) PATIENT: A CASE REPORT
According to WHO reports Hepatocellular carcinoma remains an Asian health problem. Its prevalence disproportionately shares large of the world's nearly 78%. Treatment options of HCC are limited and the effectiveness of t...
SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF CHLORZOXAZONE AND DICLOFENAC SODIUM IN SYNTHETIC MIXTURE
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of diclofenac sodium and chlorzoxazone in bulk and synthetic mixtur...
EFFECT OF SOME HERBAL DRUGS ON HAEMATOLOGICAL PROFILES OF RATS
Excessive use of oestrogen or ethinyl oestradiol (EO, a semisynthetic 17b-oestradiol as highly potent oestrogen) can cause many detrimental effects, including cancer in humans as well as in animals. On the other hand, ma...