PHENYTOIN INDUCED TOXIC EPIDERMAL NECROLYSIS (TEN) IN AN ADULT
Journal Title: Stanley Medical Journal - Year 2015, Vol 2, Issue 3
Abstract
A 38 year old male patient was treated with paracetamol and phenytoin tablets for fever and convulsions. On the fourth day of treatment, he developed generalised erythema and blistering of skin. A provisional diagnosis of toxic epidermal necrolysis was made. Both the drugs were stopped and he was treated with i.v.fluids, antibiotics and steroids. He completely recovered in 15 days. Toxic epidermal Necrolysis (TEN) is a rare immune-mediated life-threatening reaction characterised by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and death. The possibility of occurrence of TEN with phenytoin must be kept in mind. Early diagnosis of the condition and proper treatment with steroids help in recovery.
Authors and Affiliations
J. Sam Anbu Sahayam, Vasanthira K. , Jeyalalitha R, Hemavathy G
Keywords
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